ID H2QQA9_PANTR Unreviewed; 328 AA.
AC H2QQA9; A0A2J8MUQ2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Ring finger protein 175 {ECO:0000313|Ensembl:ENSPTRP00000028380.5};
GN Name=RNF175 {ECO:0000313|Ensembl:ENSPTRP00000028380.5,
GN ECO:0000313|VGNC:VGNC:672};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000028380.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000028380.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000028380.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AACZ04005062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001155746.1; XM_001155746.5.
DR AlphaFoldDB; H2QQA9; -.
DR PaxDb; 9598-ENSPTRP00000028380; -.
DR Ensembl; ENSPTRT00000030728.6; ENSPTRP00000028380.5; ENSPTRG00000016529.6.
DR GeneID; 461555; -.
DR KEGG; ptr:461555; -.
DR CTD; 285533; -.
DR VGNC; VGNC:672; RNF175.
DR eggNOG; KOG1734; Eukaryota.
DR GeneTree; ENSGT00390000013075; -.
DR HOGENOM; CLU_055016_1_0_1; -.
DR InParanoid; H2QQA9; -.
DR OMA; PYWERTH; -.
DR OrthoDB; 10447at2759; -.
DR TreeFam; TF314357; -.
DR Proteomes; UP000002277; Chromosome 4.
DR Bgee; ENSPTRG00000016529; Expressed in Brodmann (1909) area 10 and 8 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR CDD; cd16475; RING-H2_RNF121-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR040176; RNF121/RNF175.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13407:SF2; RING FINGER PROTEIN 175; 1.
DR PANTHER; PTHR13407; RNF121 PROTEIN; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 51..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 227..277
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 328 AA; 38138 MW; B8B5A5778C041CE4 CRC64;
MAAGAAARKA APVLEAPPQQ EQLSHTKLSA EDTWNLQQER MYKMHRGHDS MHVEMILIFL
CVLVIAQIVL VQWRQRHGRS YNLVTLLQMW VVPLYFTIKL YWWRFLSMWG MFSVITSYIL
FRATRKPLSG RTPRLVYKWF LLIYKLSYAF GVVGYLAIMF TMCGFNLFFK IKARDSMDFG
IVSLFYGLYY GVMGRDFAEI CSDYMASTIG FYSVSGLPTR SLSDNICAVC GQKIIVELDE
EGLIENTYQL SCNHVFHEFC IRGWCIVGKK QTCPYCKEKV DLKRMISNPW ERTHFLYGQI
LDWLRYLVAW QPVVIGIVQG INYSLGLE
//
