ID H2QQJ1_PANTR Unreviewed; 1202 AA.
AC H2QQJ1; A0A2J8L800;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Sorbin and SH3 domain containing 2 {ECO:0000313|Ensembl:ENSPTRP00000028563.5};
GN Name=SORBS2 {ECO:0000313|Ensembl:ENSPTRP00000028563.5,
GN ECO:0000313|VGNC:VGNC:12990};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000028563.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000028563.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000028563.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04005254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009446972.1; XM_009448697.2.
DR AlphaFoldDB; H2QQJ1; -.
DR STRING; 9598.ENSPTRP00000028563; -.
DR PaxDb; 9598-ENSPTRP00000028563; -.
DR Ensembl; ENSPTRT00000030924.5; ENSPTRP00000028563.5; ENSPTRG00000016657.6.
DR GeneID; 461640; -.
DR CTD; 8470; -.
DR VGNC; VGNC:12990; SORBS2.
DR eggNOG; KOG4225; Eukaryota.
DR GeneTree; ENSGT00940000157056; -.
DR HOGENOM; CLU_003951_1_0_1; -.
DR InParanoid; H2QQJ1; -.
DR OrthoDB; 5407056at2759; -.
DR TreeFam; TF320680; -.
DR Proteomes; UP000002277; Chromosome 4.
DR Bgee; ENSPTRG00000016657; Expressed in heart and 21 other cell types or tissues.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0007219; P:Notch signaling pathway; IBA:GO_Central.
DR CDD; cd11920; SH3_Sorbs2_1; 1.
DR CDD; cd11923; SH3_Sorbs2_2; 1.
DR CDD; cd11917; SH3_Sorbs2_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003127; SoHo_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR14167:SF56; DREBRIN-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF02208; Sorb; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 3.
DR SMART; SM00459; Sorb; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS50831; SOHO; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 166..227
FT /note="SoHo"
FT /evidence="ECO:0000259|PROSITE:PS50831"
FT DOMAIN 965..1024
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1040..1101
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1143..1202
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 25..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..282
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..968
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1202 AA; 134795 MW; C7A37EA7CD3204BE CRC64;
MNTDSGGCAR KRAAMSVTLT SVKRVQSSPN LLAAGRDSQS PDSAWRSYND GNQETLNGDA
TYSSLAAKGF RNVRPNLQDK RSPTQSQITV NGNSGGAVSP MSYYQRPFSP SAYSLPASLN
SSIVMQHGTS LDSTDTYPQH AQSLDGTSSS SIPLYRSSEE EKRVTVIKAP HYPGIGPVDE
SGIPTAIRTT VDRPKDWYKT MFKQIHMVHK PDDDTDMYNT PYTYNAGLYN PPYSAQSHPA
AKTQTYRPLS KSHSDNSPNA FKDVSSPVPP PHVPPPVPPL RPRDRSSTEK HDWDPPDRKV
DTRKFRSEPR SIFEYEPGKS SILQHERPAS LYQSSIDRSL ERPMSSASMA SDFRKRRKSE
PAVGPPRGLG DQSSSRTSPG RVDLPGSSTS LTKSFTSSSP SSPSRAKGGD DSKICPSLCS
YSGLNGNPSS ELDYCSTYRQ HLDVPRDSPR AISFKNGWQM ARQNAEIWSS TEETVSPKIK
SRSCDDLLND DCDSFPDPKI KSESMGSLLC EEDSKESCPM AWGSPHIQEV RSNGRSRTRH
RSARSAPGFL KMYKKMHRIN RKDLMNSEVI CSVKSRILQY ESEQQHQGLL HAWSQSSTEE
VPRDMVPTRI SEFEKLIQKS KSMPNLGDDM LSPVTLEPPQ NGLCPKRRFS IEYLLEEENQ
SGRPAQGQRG CQSSALVPIH IEVTSDEQPR AHVEFSDSDQ DGVVSDHSDY IHLEGSSFCS
ESDFDHFSFT SSESFYGSSH HHHHHHHHHH HHRHLISSCK GRCPASYTRF TTMLKHERAR
HENTEEPRRQ EMDPGLSKLA FLVSPVPFRR KKNSAPKKQT EKAKCKASVF EALDSALKDI
CDQIKAEKKR GSLPDNSILH RLISELLPDV PDRNSSLRAL RRSPLHQPLH PLSQDGAIHC
PPYQDDCGRM PHSASFQDGD TASNSYHHQD RGGALQDRES PRSYSSTLTD MGRSAPRERR
GTPEKEKLPA KAVYDFKAQT SKELSFKKGD TVYILRKIDQ NWYEGEHHGR VGIFPISYVE
KLTPPEKAQP ARPPPPAQPG EIGEAIAKYN FNADTNVELS LRKGDRVILL KRVDQNWYEG
KIPGTNRQGI FPVSYVEVVK KNTKGAEDYP DPPIPHSYSS DRIHSLSSNK PQRPVFTHEN
IQGGGEPFQA LYNYTPRNED ELELRESDVI DVMEKCDDGW FVGTSRRTKF FGTFPGNYVK
RL
//
