ID H2QTQ3_PANTR Unreviewed; 1410 AA.
AC H2QTQ3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRK {ECO:0000313|Ensembl:ENSPTRP00000031727.7,
GN ECO:0000313|VGNC:VGNC:11196};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000031727.7, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000031727.7, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000031727.7}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR EMBL; AACZ04054413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04054414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04054415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000034323.7; ENSPTRP00000031727.7; ENSPTRG00000018587.7.
DR VGNC; VGNC:11196; PTPRK.
DR eggNOG; KOG4228; Eukaryota.
DR GeneTree; ENSGT00940000156249; -.
DR HOGENOM; CLU_001645_0_2_1; -.
DR TreeFam; TF312900; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000018587; Expressed in temporal lobe and 21 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14636; R-PTPc-K-2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF11; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 724..745
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..164
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 166..251
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 264..359
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 461..565
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 858..1112
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1032..1103
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1144..1406
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1320..1397
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1410 AA; 159235 MW; 81B6696EB4458940 CRC64;
FLLGGCTFDD GPGACDYHQD LYDDFEWVHV SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK
ARLQLPTMKE NDTHCIDFSY LLYSQKGLNP GTLNILVRVN KGPLANPIWN VTGFTGRDWL
RAELAVSTFW PNEYQVIFEA EVSGGRSGYI AIDDIQVLSY PCDKSPHFLR LGDVEVNAGQ
NATFQCIATG RDAVHNKLWL QRRNGEDIPV AQTKNINHRR FAASFRLQEV TKTDQDLYRC
VTQSERGSGV SNFAQLIVRE PPRPIAPPQL LGVGPTYLLI QLNANSIIGD GPIILKEVEY
RMTSGSWTET HAVNAPTYKL WHLDPDTEYE IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM
RTPKTLKIAE IQARRIAVDW ESLGYNITRC HTFNVTICYH YFRGHNESKA DCLDMDPKAP
QHVVNHLPPY TNVSLKMILT NPEGRKESEE TIIQTDEDVP GPVPVKSLQG TSFENKIFLN
WKEPLDPNGI ITQYEISYSS IRSFDPAVPV AGPPQTVSNL WNSTHHVFMH LHPGTTYQFF
IRASTVKGFG PATAINVTTN ISAPTLPDYE GVDASLNETA TTITVLLRPA QAKGAPISAY
QIVVEELHPH RTKREAGAME CYQVPVTYQN AMSGGAPYYF AAELPPGNLP EPAPFTVGDN
RTYQGFWNPP LAPRKGYNIY FQAMSSVEKE TKTQCVRIAT KAAATEEPEV IPDPAKQTDR
VVKIAGISAG ILVFILLLLV VILIVKKSKL AKKRKDAMGN TRQEMTHMVN AMDRSYADQS
TLHAEDPLSI TFMDQHNFSP RYENHSATAE SSRLLDVPRY LCEGTESPYQ TGQLHPAIRV
ADLLQHINLM KTSDSYGFKE EYESFFEGQS ASWDVAKKDQ NRAKNRYGNI IAYDHSRVIL
QPVEDDPSSD YINANYIDGY QRPSHYIATQ GPVHETVYDF WRMIWQEQSA CIVMVTNLVE
VGRVKCYKYW PDDTEVYGDF KVTCVEMEPL AEYVVRTFTL ERRGYNEIRE VKQFHFTGWP
DHGVPYHATG LLSFIRRVKL SNPPSAGPIV VHCSAGAGRT GCYIVIDIML DMAEREGVVD
IYNCVKALRS RRINMVQTEE QYIFIHDAIL EACLCGETAI PVCEFKAAYF DMIRIDSQTN
SSHLKDEFQT LNSVTPRLQA EDCSIACLPR NHDKNRFMDM LPPDRCLPFL ITIDGESSNY
INAALMDSYR QPAAFIVTQY PLPNTVKDFW RLVYDYGCTS IVMLNEVDLS QGCPQYWPEE
GMLRYGPIQV ECMSCSMDCD VINRIFRICN LTRPQEGYLM VQQFQYLGWA SHREVPGSKR
SFLKLILQVE KWQEECEEGE GRTIIHCLNG GGRSGMFCAI GIVVEMVKRQ NVVDVFHAVK
TLRNSKPNMV EAPEQYRFCY DVALEYLESS
//
