ID H2QY10_PANTR Unreviewed; 253 AA.
AC H2QY10; A0A2J8NAY7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Paired related homeobox 2 {ECO:0000313|EMBL:JAA03065.1, ECO:0000313|Ensembl:ENSPTRP00000036711.3};
GN Name=PRRX2 {ECO:0000313|EMBL:JAA03065.1,
GN ECO:0000313|Ensembl:ENSPTRP00000036711.3, ECO:0000313|VGNC:VGNC:4831};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000036711.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000036711.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA03065.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03065.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA42880.1}, Skin {ECO:0000313|EMBL:JAA32535.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA15188.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000036711.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the paired homeobox family.
CC {ECO:0000256|ARBA:ARBA00005733}.
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DR EMBL; AACZ04069124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01008273; JAA03065.1; -; mRNA.
DR EMBL; GABF01006957; JAA15188.1; -; mRNA.
DR EMBL; GABD01000565; JAA32535.1; -; mRNA.
DR EMBL; GABE01001859; JAA42880.1; -; mRNA.
DR RefSeq; XP_016817320.1; XM_016961831.1.
DR STRING; 9598.ENSPTRP00000036711; -.
DR PaxDb; 9598-ENSPTRP00000036711; -.
DR Ensembl; ENSPTRT00000039734.4; ENSPTRP00000036711.3; ENSPTRG00000021461.7.
DR GeneID; 464792; -.
DR KEGG; ptr:464792; -.
DR CTD; 51450; -.
DR VGNC; VGNC:4831; PRRX2.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000161643; -.
DR HOGENOM; CLU_087323_0_0_1; -.
DR OMA; QGVNMAD; -.
DR OrthoDB; 3685623at2759; -.
DR TreeFam; TF351612; -.
DR Proteomes; UP000002277; Chromosome 9.
DR Bgee; ENSPTRG00000021461; Expressed in fibroblast and 7 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR InterPro; IPR043378; PRRX1/2.
DR PANTHER; PTHR46385; PAIRED MESODERM HOMEOBOX PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46385:SF3; PAIRED MESODERM HOMEOBOX PROTEIN 2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 102..162
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 230..243
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 104..163
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..28
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 253 AA; 27079 MW; C7A861D46DC46DD3 CRC64;
MDSAAAAFAL DKPALGPGPP PPPPALGPGD CAQARKNFSV SHLLDLEEVA AAGRLAARPG
ARAEAREGAA REPSGGSSGS EAAPQDGECP SPGRGSAAKR KKKQRRNRTT FNSSQLQALE
RVFERTHYPD AFVREELARR VNLSEARVQV WFQNRRAKFR RNERAMLASR SASLLKSYSQ
EAAIEQPVAP RPTALSPDYL SWTASSPYST VPPYSPGSSG PATPGVNMAN SIASLRLKAK
EFSLHHSQVP TVN
//
