ID H2R3S5_PANTR Unreviewed; 833 AA.
AC H2R3S5; A0A2J8QEM7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Intraflagellar transport 88 {ECO:0000313|Ensembl:ENSPTRP00000045992.5};
GN Name=IFT88 {ECO:0000313|Ensembl:ENSPTRP00000045992.5,
GN ECO:0000313|VGNC:VGNC:13116};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000045992.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000045992.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000045992.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04071643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009424916.2; XM_009426641.2.
DR RefSeq; XP_009424917.2; XM_009426642.2.
DR RefSeq; XP_009424918.2; XM_009426643.2.
DR AlphaFoldDB; H2R3S5; -.
DR STRING; 9598.ENSPTRP00000045992; -.
DR PaxDb; 9598-ENSPTRP00000045992; -.
DR Ensembl; ENSPTRT00000043050.5; ENSPTRP00000045992.5; ENSPTRG00000005685.6.
DR GeneID; 452461; -.
DR CTD; 8100; -.
DR VGNC; VGNC:13116; IFT88.
DR eggNOG; KOG2003; Eukaryota.
DR GeneTree; ENSGT00390000015473; -.
DR HOGENOM; CLU_010738_1_0_1; -.
DR InParanoid; H2R3S5; -.
DR OrthoDB; 312444at2759; -.
DR TreeFam; TF313218; -.
DR Proteomes; UP000002277; Chromosome 13.
DR Bgee; ENSPTRG00000005685; Expressed in testis and 21 other cell types or tissues.
DR GO; GO:0005814; C:centriole; IBA:GO_Central.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0097546; C:ciliary base; IBA:GO_Central.
DR GO; GO:0030992; C:intraciliary transport particle B; IEA:Ensembl.
DR GO; GO:0097730; C:non-motile cilium; IBA:GO_Central.
DR GO; GO:0019894; F:kinesin binding; IBA:GO_Central.
DR GO; GO:0060122; P:inner ear receptor cell stereocilium organization; IBA:GO_Central.
DR GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR GO; GO:0001822; P:kidney development; IBA:GO_Central.
DR GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central.
DR GO; GO:0045724; P:positive regulation of cilium assembly; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44117; INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG; 1.
DR PANTHER; PTHR44117:SF1; INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG; 1.
DR Pfam; PF12895; ANAPC3; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00671; SEL1; 4.
DR SMART; SM00028; TPR; 11.
DR SUPFAM; SSF81901; HCP-like; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 7.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 242..275
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 281..314
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 493..526
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 527..560
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 561..594
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 595..628
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 629..662
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 122..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 94256 MW; 383882C4E89AF0DA CRC64;
MKFTNTKVQM MQNVHLAPET DEDDLYSGYN DYNPIYDIEE LENDAAFQQA VRTSHGRRPP
ITAKISSTAV TRPIATGYGS KTSLASSIGR PMTGAIQDGV TRPMTAVRAA GFTKAALRGS
AFDPLSQSRG PASPLEAKKK DSPEEKIKQL EKEVNELVEE SCIANSCGDL KLALEKAKDA
GRKERVLVRQ REQVTTPENI NLDLTYSVLF NLASQYSVNE MYAEALNTYQ VIVKNKMFSN
AGILKMNMGN IYLKQRNYSK AIKFYRMALD QVPSVNKQMR IKIMQNIGVT FIQAGQYSDA
INSYEHIMSM APNLKAGYNL TICYFAVGDR EKMKKAFQKL ITVPLEIDED KYISPSDDPH
TNLVTEAIKN DHLRQMERER KAMAEKYIMT SAKLIAPVIE TSFAAGYDWC VEVVKASQYV
ELANDLEINK AVTYLRQKDY NQAVEILKVL EKKDSRVKSA AATNLSALYY MGKDFAQASS
YADIAVNSDR YNPAALTNKG NTVFANGDYE KAAEFYKEAL RNDSSCTEAL YNIGLTYEKL
NRLDEALDCF LKLHAILRNS AEVLYQIANI YELMENPSQA IEWLMQVVSV IPTDPQVLSK
LGELYDREGD KSQAFQYYYE SYRYFPCNIE VIEWLGAYYI DTQFWEKAIQ YFERASLIQP
TQVKWQLMVA SCFRRSGNYQ KALDTYKDTH RKFPENVECL RFLVRLCTDL GLKDAQEYAR
KLKRLEKMKE IREQRIKSGR DGSGGSRGKR EGSASGDSGQ NYSASSKGER LSARLRALPG
TNEPYESSSN KEIDASYVDP LGPQIERPKT AAKKRIDEDD FADEELGDDL LPE
//
