ID H2R9Q0_PANTR Unreviewed; 662 AA.
AC H2R9Q0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Outer dynein arm-docking complex subunit 4 {ECO:0000256|ARBA:ARBA00034139};
DE AltName: Full=Tetratricopeptide repeat protein 25 {ECO:0000256|ARBA:ARBA00034143};
GN Name=ODAD4 {ECO:0000313|Ensembl:ENSPTRP00000053068.3,
GN ECO:0000313|VGNC:VGNC:57302};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000053068.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000053068.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000053068.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
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DR EMBL; AACZ04038962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04038963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04038964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2R9Q0; -.
DR PaxDb; 9598-ENSPTRP00000053068; -.
DR Ensembl; ENSPTRT00000059824.3; ENSPTRP00000053068.3; ENSPTRG00000030946.4.
DR VGNC; VGNC:57302; ODAD4.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00390000007911; -.
DR HOGENOM; CLU_089177_0_0_1; -.
DR InParanoid; H2R9Q0; -.
DR OMA; NKEDLCF; -.
DR TreeFam; TF323661; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000030946; Expressed in testis and 16 other cell types or tissues.
DR GO; GO:0097728; C:9+0 motile cilium; IEA:Ensembl.
DR GO; GO:0097729; C:9+2 motile cilium; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0120228; C:outer dynein arm docking complex; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0090660; P:cerebrospinal fluid circulation; IEA:Ensembl.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0120197; P:mucociliary clearance; IEA:Ensembl.
DR GO; GO:0036158; P:outer dynein arm assembly; IEA:Ensembl.
DR GO; GO:0120229; P:protein localization to motile cilium; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR040111; ODAD4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23040:SF1; OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR23040; UNCHARACTERIZED; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 360..393
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 158..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 443..470
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 167..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..662
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 662 AA; 75184 MW; 9A2A584E3BAEB592 CRC64;
MSDTEGETLR STFPSYMAEG ERLYLCGEFS KAAQSFSNAL YLQDGDKNCL VARSKCFLKM
GDLERSLKDA EASLQSDPAF CKGILQKAET LYTMGDFEFA LVFYHRGYKL RPDREFRVGI
QKAQEAINNS VGSPSSIKLE NKGDLSFLSK QAENIKAQQK PQPMKHLLHP TKGEPKRKGS
LKSEKTVRQL LGELYVDKEY LEKLLLDEDL IKGTMKGGLT VEDLIMTGIN YLDTHSNFWR
QQKPIYARER DRKLMQEKWL RDHKRRPSQT AHYILKSLED IDMLLTSGSA EGSLQKAEKV
LKKVLEWNKE EVPNKDELVG NLYSCIGNAQ IDLGQMEAAL QSHRKDLEIA KEYDLPDAKS
RALDNIGRVF ARVGKFQQAI DTWEEKIPLA KTTLEKTWLF HEIGRCYLEL DQAWQAQNYG
EKSQQCAKEE GDIEWQLNAS VLVAQAQVKL RDFESAVNNF EKALERAKLV HNNEAQQAII
SVSLSTRRAS GVRSGVGWSE ASLYEDRIIT REKDMRRVRD EPEKVVKQWD HIEDEKETDE
DNEAFGEALQ SPASGKQSVE AGKARSDLGA VAKGLSGELG TRSGETGGKL LEAGRRESRE
IYRRPSGELE QRLSGEFSRQ EPEELKKLSE VGRREPEELG KTQFGEIGET KKTGNEMEKE
YE
//
