ID H2RB02_PANTR Unreviewed; 415 AA.
AC H2RB02;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Arylsulfatase B {ECO:0000313|Ensembl:ENSPTRP00000054793.3};
GN Name=ARSB {ECO:0000313|Ensembl:ENSPTRP00000054793.3,
GN ECO:0000313|VGNC:VGNC:11821};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000054793.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000054793.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000054793.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; AACZ04061861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04061862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04061863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04061864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04061865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009447246.2; XM_009448971.2.
DR AlphaFoldDB; H2RB02; -.
DR Ensembl; ENSPTRT00000062238.3; ENSPTRP00000054793.3; ENSPTRG00000017019.7.
DR GeneID; 737316; -.
DR CTD; 411; -.
DR VGNC; VGNC:11821; ARSB.
DR eggNOG; KOG3867; Eukaryota.
DR GeneTree; ENSGT00940000158270; -.
DR HOGENOM; CLU_006332_10_1_1; -.
DR OMA; HEHCVFI; -.
DR OrthoDB; 2913702at2759; -.
DR TreeFam; TF314186; -.
DR Proteomes; UP000002277; Chromosome 5.
DR Bgee; ENSPTRG00000017019; Expressed in adult mammalian kidney and 20 other cell types or tissues.
DR GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:UniProt.
DR CDD; cd16029; 4-S; 1.
DR Gene3D; 3.30.1120.10; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR047115; ARSB.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR10342; ARYLSULFATASE; 1.
DR PANTHER; PTHR10342:SF272; ARYLSULFATASE B; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
DR PROSITE; PS00149; SULFATASE_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..40
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 41..415
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014170150"
FT DOMAIN 47..363
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
SQ SEQUENCE 415 AA; 46222 MW; 509A8D11C5D8641C CRC64;
MGPRGAASLP RGPGPRRLLL PVVLPLLLLL LLLLAPPGSG AGASRPPHLV FLLADDLGWN
DVGFHGSRIR TPHLDALAAG GVLLDNYYTQ PLCTPSRSQL LTGRYQIRTG LQHQIIWPCQ
PSCVPLDEKL LPQLLKEAGY TTHMVGKWHL GMYRKECLPT RRGFDTYFGY LLGSEDYYSH
ERCTLIDALN VTRCALDFRD GEEVATGYKN MYSTNIFTKR AIALITNHPP EKPLFLYLAL
QSVHEPLQVP EEYLKPYDFI QDKNRHHYAG MVSLMDEAVG NVTAALKSSG LWNNTVFIFS
TDNGGQTLAG GNNWPLRGRK WSLWEGGVRG VGFVASPLLK QKGVKNRELI HISDWLPTLV
KLARGHTNGT KPLDGFDVWK TISEGSPSPR IELLHNIDPN FVDSSPYWPE CSLLL
//
