ID H2RBC7_PANTR Unreviewed; 2068 AA.
AC H2RBC7; A0A2J8M979;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Dedicator of cytokinesis 9 {ECO:0000313|Ensembl:ENSPTRP00000055482.3};
GN Name=DOCK9 {ECO:0000313|Ensembl:ENSPTRP00000055482.3,
GN ECO:0000313|VGNC:VGNC:5056};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000055482.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000055482.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000055482.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04072696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001145769.2; XM_001145769.4.
DR PaxDb; 9598-ENSPTRP00000055482; -.
DR Ensembl; ENSPTRT00000063936.3; ENSPTRP00000055482.3; ENSPTRG00000005991.6.
DR VGNC; VGNC:5056; DOCK9.
DR eggNOG; KOG1997; Eukaryota.
DR GeneTree; ENSGT00940000155972; -.
DR HOGENOM; CLU_000624_1_0_1; -.
DR OrthoDB; 5480873at2759; -.
DR TreeFam; TF313629; -.
DR Proteomes; UP000002277; Chromosome 13.
DR Bgee; ENSPTRG00000005991; Expressed in lung and 21 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 173..280
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 639..817
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1604..2068
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 289..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1240..1281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2068 AA; 236427 MW; 92361FD2E0A8F971 CRC64;
MQADKCRTSS RSVKKELVIE SPLQYKDAAQ GEVEAESPGP VPAKPKLIEP LDYENVIVQK
KTQILNDCLR EMLLFPYDDF QTAILRRQGR YICSTVPAKA EEEAQSLFVT ECIKTYNSDW
HLVNYKYEDY SGEFRQLPNK VVKLDKLPVH VYEVDEEVDK DEDAASLGSQ KGGITKHGWL
YKGNMNSAIS VTMRSFKRRF FHLIQLGDGS YNLNFYKDEK ISKEPKGSIF LDSCMGVVQN
NKVRRFAFEL KMQDKSSYLL AADSEVEMEE WITILNKILQ LNFEAAMQEK RNGDSHEDDE
QSKLEGSGSG LDSYLPELAK SAREAEIKLK SESRVKLFYL DPDAQKLDFS SAEPEVKSFE
EKFGKRILVK CNDLSFNLQC CVAENEEGPT TNVEPFFVTL SLFDIKYNRK ISADFHVDLN
HFSVRQMLAT TSPALMNGSG QSPSVLKGIL HEAAMQYPKQ GIFSVTCPHP DIFLVARIEK
VLQGSITHCA EPYMKSSDSS KVAQKVLKNA KQACQRLGQY RMPFAWAART LFKDASGNLD
KNARFSAIYR QDSNKLSNDD MLKLLADFRK PEKMAKLPVI LGNLDITIDN VSSDFPNYVN
SSYIPTKQFE TSSKTPITFE VEEFVPCIPK HTQPYTIYTN HLYVYPKYLK YDSQKSFAKA
RNIAICIEFK DSDEEDSQPL KCIYGRPGGP VFTRSAFAAV LHHHQNPEFY DEIKIELPTQ
LHEKHHLLLT FFHVSCDNSS KGSTKKRDVV ETQVGYSWLP LLKDGRVVTS EQHIPVSANL
PSGYLGYQEL GMGRHYGPEI KWVDGGKPLL KISTHLVSTV YTQDQHLHNF FQYCQKTESG
AQALGNELVK YLKSLHAMEG HVMIAFLPTI LNQLFRVLTR ATQEEVAVNV TRVIIHVVAQ
CHEEGLESHL RSYVKYAYKA EPYVASEYKT VHEELTKSMT TILKPSADFL TSNKLLKYSW
FFFDVLIKSM AQHLIENSKV KLLRNQRFPA SYHHAVETVV NMLMPHITQK FRDNPEASKN
ANHSLAVFIK RCFTFMDRGF VFKQINNYIS CFAPGDPKTL FEYKFEFLRV VCNHEHYIPL
NLPMPFGKGR IQRYQDLQLD YSLTDEFCRN HFLVGLLLRE VGTALQEFRE VRLIAISVLK
NLLIKHSFDD RYASRSHQAR IATLYLPLFG LLIENVQRIN VRDVSPFPVN AGMTVKDESL
ALPAVNPLVT PQKGSSLDNS LHKDLLGAIS GIASPYTTST PNINSVRNAD SRGSLISTDS
GNSLPERNSE KSNSLDKHQQ SSTLGNSVVR CDKLDQSEIK SLLMCFLYIL KSMSDDALFT
YWNKASTSEL MDFFTISEVC LHQFQYMGKR YIARTGMMHA RLQQLGSLDN SLTFNHSYGH
SDADVLHQSL LEANIATEVC LTALDTLSLF TLAFKNQLLA DHGHNPLMKK VFDVYLCFLQ
KHQSETALKN VFTALRSLIY KFPSTFYEGR ADMCAALCYE ILKCCNSKLS SIRTEASQLL
YFLMRNNFDY TGKKSFVRTH LQVIISVSQL IADVVGIGGT RFQQSLSIIN NCANSDRLIK
HTSFSSDVKD LTKRIRTVLM ATAQMKEHEN DPEMLVDLQY SLAKSYASTP ELRKTWLDSM
ARIHVKNGDL SEAAMCYVHV TALVAEYLTR KEAVQWEPPL LPHSHSACLR RSRGGMFRQG
CTAFRVITPN IDEEASMMED VGMQDVHFNE DVLMELLEQC ADGLWKAERY ELIADIYKLI
IPIYEKRRDF ERLAHLYDTL HRAYSKVTEV MHSGRRLLGT YFRVAFFGQA AQYQFTDSET
DVEGFFEDED GKEYIYKEPK LTPLSEISQR LLKLYSDKFG SENVKMIQDS GKVNPKDLDS
KYAYIQVTHV IPFFDEKELQ ERKTEFERSH NIRRFMFEMP FTQTGKRQGG VEEQCKRRTI
LTAIHCFPYV KKRIPVMYQH HTDLNPIEVA IDEMSKKVAE LRQLCSSAEV DMIKLQLKLQ
GSVSVQVNAG PLAYARAFLD DTNTKRYPDN KVKLLKEVFR QFVEACGQAL AVNERLIKED
QLEYQEEMKA NYREMAKELS EIMHEQLG
//
