ID H2RS57_TAKRU Unreviewed; 309 AA.
AC H2RS57;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=C1q and TNF related 2 {ECO:0000313|Ensembl:ENSTRUP00000002973.3};
GN Name=C1QTNF2 {ECO:0000313|Ensembl:ENSTRUP00000002973.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000002973.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000002973.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000002973.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003970477.2; XM_003970428.2.
DR AlphaFoldDB; H2RS57; -.
DR STRING; 31033.ENSTRUP00000002973; -.
DR Ensembl; ENSTRUT00000002991.3; ENSTRUP00000002973.3; ENSTRUG00000001288.3.
DR GeneID; 101067709; -.
DR KEGG; tru:101067709; -.
DR CTD; 114898; -.
DR eggNOG; ENOG502QT1U; Eukaryota.
DR GeneTree; ENSGT00940000159591; -.
DR HOGENOM; CLU_001074_0_3_1; -.
DR InParanoid; H2RS57; -.
DR OMA; MPGPCSC; -.
DR OrthoDB; 3013859at2759; -.
DR TreeFam; TF329591; -.
DR Proteomes; UP000005226; Chromosome 14.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427:SF28; COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 2.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..309
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025637608"
FT DOMAIN 159..295
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 53..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..73
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 309 AA; 32543 MW; B5AD56DF3B59422B CRC64;
MYLCRSCFSA VTVMLQMCVM CCLLSVACSQ SRYALPKRGR NITIHSSQLI CSLPGPAGPD
GNPGPPGSPG AMGPMGPPGK DGPDGKDGDK GDKGDAGDPG RTGNPGKPGV KGREGVIGRA
GLRGLKGLRG STGAAGTKGP KGEAGDVGQE GAAGRCNCGT AARSAFSVAV TKSYPKERLP
IRFSRVLLNE GNHYNTTTGK FVCAIPGVYY FSYDITLANK HLAIGLVHNG HYKIKTFDAN
TGNHDVASGS TVLRLQKSDQ VWLQIFYSEQ NGLFFDPFWT DSTFTGFLVH ADQDYLNEAD
TKANAQDDS
//
