ID H2SXA8_TAKRU Unreviewed; 1162 AA.
AC H2SXA8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Structural maintenance of chromosomes 3 {ECO:0000313|Ensembl:ENSTRUP00000017046.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000017046.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000017046.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000017046.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005917}.
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DR AlphaFoldDB; H2SXA8; -.
DR Ensembl; ENSTRUT00000017119.3; ENSTRUP00000017046.3; ENSTRUG00000006942.3.
DR eggNOG; KOG0964; Eukaryota.
DR GeneTree; ENSGT00580000081628; -.
DR HOGENOM; CLU_001042_5_0_1; -.
DR InParanoid; H2SXA8; -.
DR OMA; DQHQSMR; -.
DR TreeFam; TF105602; -.
DR Proteomes; UP000005226; Chromosome 17.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 2.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 475..588
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 188..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 344..448
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 620..798
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 907..934
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1012..1035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1162 AA; 135119 MW; 0F3E2BE8071E2E27 CRC64;
MPFTFVALSP QEGTGPRVIS AFVEIIFDNS DNRLPIDKEE VSLRRVIGAK KDQYFLDKKM
VTKNDVMNLL ESAGFSRSNP YYIVKQGKIN QMATAPDSQR LKLLREVAGT RVYDERKEES
ISLMKETEGK REKINELLKY IEERLHTLED EKEELAQYQK WDKMRRALEY TIYNQELNET
RAKLDELSSK RETCGDKSRQ LRDAQQDARD KVEETERVVR ELKSKISAMK EEKEQLSAER
QEQIKQRTKL ELKAKDLQDE LAGNSEQRKR LLKERQKLLE KIEEKQKELQ ETEPKFSMVK
EKEERGISRL AQATQERTDL YAKQGRGSQF TSKEDRDKWI KKELKSLDQA INDKKRQIAA
IHKDLEDTET NKEKNLEQYT KLDQDLNEVK TRVEELDKKY YEVKNRKDEL QSERNYLWRE
ENAEQQALAA KREDLEKKQQ LLRAATGKAI LNGIDSINKV LEHFRRKGIN QHVISGYHGI
VMNNFECDPA FYTCVEVTAG TRLFYHIVET DEVSTKILME FNKMNLPGEV TFLPLTKLDV
RDTAYPETND AIPMISKLRY NTNFDKAFKH VFGKTLICRS MEVSTQLARA FTMDCITLEG
DQVSHRGALT GGYYDTRKSR LELQKDMRKA EEELGELEAK LNENLRRNIE RINNEIDQLM
NQMQQIETQQ RKFKASRDSI LSEMKMLKEK RQQSEKTFMP KQRSLQSLEA SLHAMESTRE
SLKAELGTDL LSQLSLEDQR RVDDLNDEIR QLQQDNRQLL NERIKLEGIM TRVETYLNEN
LRKRLDQVEQ ELNELRETEG GTVLTATTSE LDGINKRVKD TLARSDDLDT LIDKTEGEIK
EHIRSMDRWK NIEKEQNDAI NHDTKELEKM TNRQGMLLKK KEECMKKIRE LGSLPQEAFE
KYQTLTLKQL FRKLEQCNTE LKKYSHVNKK ALDQFVNFSE QKEKLIKRQE ELDRGYKSIM
ELMNVLELRK YEAIQLTFKQ VSKNFSEVFQ KLVPGGKATL VMKKGDAEGS QSQDEGESGV
DSERGSSSQS SVPSVDQFTG VGIRVSFTGK QGEMREMQQL SGGQKSLVAL ALIFAIQKCD
PAPFYLFDEI DQALDAQHRK AVSDMIVELA GHAQFITTTF RPELLESADK FYGVKFRNKV
SHIDVITAEQ AKDFVEDDTT HG
//
