ID H2SYH9_TAKRU Unreviewed; 770 AA.
AC H2SYH9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Cyclin-F {ECO:0000256|ARBA:ARBA00019493};
GN Name=ccnf {ECO:0000313|Ensembl:ENSTRUP00000017467.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000017467.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000017467.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000017467.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential for the control of the cell cycle at the G2/M
CC (mitosis) transition. {ECO:0000256|ARBA:ARBA00003222}.
CC -!- SUBUNIT: Interacts with the CDK1 protein kinase to form a
CC serine/threonine kinase holoenzyme complex also known as maturation
CC promoting factor (MPF). The cyclin subunit imparts substrate
CC specificity to the complex. {ECO:0000256|ARBA:ARBA00025821}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}.
CC Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC {ECO:0000256|ARBA:ARBA00006955}.
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DR AlphaFoldDB; H2SYH9; -.
DR STRING; 31033.ENSTRUP00000080082; -.
DR Ensembl; ENSTRUT00000017541.3; ENSTRUP00000017467.3; ENSTRUG00000007108.3.
DR eggNOG; KOG0654; Eukaryota.
DR GeneTree; ENSGT00810000125541; -.
DR TreeFam; TF101006; -.
DR Proteomes; UP000005226; Chromosome 5.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd20521; CYCLIN_CCNF_rpt1; 1.
DR CDD; cd22082; F-box_FBXO1; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR048258; Cyclins_cyclin-box.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR PANTHER; PTHR10177:SF496; CYCLIN-F; 1.
DR PANTHER; PTHR10177; CYCLINS; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
DR SUPFAM; SSF81383; F-box domain; 1.
DR PROSITE; PS00292; CYCLINS; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 29..76
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 566..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 770 AA; 85909 MW; DAB3BE4635DDE306 CRC64;
MKAGVLHCRC SKCYSVPTKK RVRKRVPPAL GLLSLPEEVL LCILQCLSAE DLLSVRAAHS
QLRDIVDNHS SVWARVSFRD SWPSPNSLWL FERAAEKGNF EAAVKLGIAY LYNEGPLLSD
EGRADVCGRK AAHFFSLAET LRAPSVNPFI WVFIRPPWSP TGSCCKAVVF DHLKAECEKH
VEKRGPLLHC LARVLQLFEV SLSEAVSMLE RSSQAGCLQS SYLLWEHKRR GAMTDPGRYL
QCIRTLRDYA GKGCWEAQLS LAKVCSCGNP LGLESKACSD LVSQLFSSAH PASQHCSLGA
LRPGINDTMR YILVDWLVEV TTMKDFSSLT LHVTVGCVDR YLALRSVPKA RLQLLGIACM
VVCTRYMSKE ILTIREAVWL TDNTYKYEDL VRMMGEVVSV LEGKIRCPTL LDYGEVLLSL
LPLERRTTHL FSYICELSLL YSPLATPPPA KLACAALLLT RALHHYAPLW PSLLVDYTGF
SKQDLVSLSM LLYVKCFSQD VPKDYRHVSL TGVKQRFEDE VYHQISKEKV ADYKELCQIL
EIPEEAPQME PSCSNGHPTD IHAFLASPTS TNKRRRDDAM QSRRESFVAT PTAELSKQEE
TLLGDILDWS LDTSCSGYEG DQDEDSEGEK DVDVFGLLNS DTYAKQEHCR ALSSDEDSFC
EDEREAGKNQ PSWEPFSFSS GYSSIQSVSP SSSCSASSPL MPCTFKTITT SSGTAFKGQP
GFRLLVPMQR PRGTSSKQVK RKNSAAHSGG ELEREDEEDE YTTKPGFLSL
//
