ID H2T112_TAKRU Unreviewed; 755 AA.
AC H2T112;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Actin filament-associated protein 1-like 1 {ECO:0000256|ARBA:ARBA00016930};
GN Name=afap1l1 {ECO:0000313|Ensembl:ENSTRUP00000018350.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000018350.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000018350.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000018350.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in podosome and invadosome formation.
CC {ECO:0000256|ARBA:ARBA00002089}.
CC -!- SUBCELLULAR LOCATION: Cell projection, invadopodium
CC {ECO:0000256|ARBA:ARBA00004264}. Cell projection, podosome
CC {ECO:0000256|ARBA:ARBA00004188}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_011609107.1; XM_011610805.1.
DR AlphaFoldDB; H2T112; -.
DR Ensembl; ENSTRUT00000018426.3; ENSTRUP00000018350.3; ENSTRUG00000007424.3.
DR GeneID; 101072264; -.
DR KEGG; tru:101072264; -.
DR CTD; 566757; -.
DR GeneTree; ENSGT00950000183067; -.
DR OrthoDB; 2912091at2759; -.
DR Proteomes; UP000005226; Chromosome 14.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0002102; C:podosome; IEA:UniProtKB-SubCell.
DR CDD; cd13307; PH2_AFAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR030113; AFAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR14338; ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER; 1.
DR PANTHER; PTHR14338:SF1; ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 1; 1.
DR Pfam; PF00169; PH; 2.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 226..322
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 404..498
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 96..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..131
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 755 AA; 84496 MW; F2422E9E6C0FF2D5 CRC64;
MVGLSSTTAE AMELLVSEVS ILLKMLDQET LSSSVQEKKT SVWNLLQQIE PSGTDYIYMN
SSVYRNGTSF VESLFEKFDC ELGGLKDITD ALKEDKSTQD DTLNQQNCGN STAPHCGDSP
PPLPTTPPPE EYYEEAVPLS PGTMPEYIIT RVRPSPPNSI EDGYEDTETH YPSTCISSHR
KNSYNDSDAL SSSYESYEED DEERSHGVQL THQWPSNESS LPPARDCRIC AFLLRKKRFG
QWAKQFTVIR ENRLQCYKSS KDTCPYVDLL LPQCTVVYAP KDSKRKHHEL RFTLPNGDAL
VLAVQSKEQA HRWLRVVREV SGKNAGAEES ASPIIPRKTE LDKRLSAERN TSDSDSVGVS
TGENGRENGK VKRGAFAAGR KITRIISFSK KKSPRSGDPR VSYSNPRQGY LSVLVNQMWR
EQWCCLCQGA LHFYHDKGDA RTSMPSLPLH GCEVVPGLGP KHPFAFRILR NNTEMAALEA
SSSEDLGRWL GVLLAETGSA ADPESLHYDC VDVETIANIR DAVRHSFLWA TSSSSTSTDP
RTYDEVSNED MQSGENCRQQ PGNQGKRRSS FSSTDSDRTK PLVSLKRTGS NANQYGRYGK
TRAEEDAKRY LKEKEELEKE KEEIRNALLT LRQEKRELKE EIKTASGSRK SSLTKRVSEL
EEACRVKEAD RVDLELQLTQ VQENLKKSLA GGVLGAPVEA KPPLKGSRKT TQNIYSETLP
VNCATELRRR PPSVYASTGT VMQKAKEWES KKGTK
//
