ID   H2T3A0_TAKRU            Unreviewed;       193 AA.
AC   H2T3A0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Exosome component 1 {ECO:0000313|Ensembl:ENSTRUP00000019138.3};
GN   Name=exosc1 {ECO:0000313|Ensembl:ENSTRUP00000019138.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000019138.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000019138.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000019138.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
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DR   RefSeq; XP_003972075.1; XM_003972026.2.
DR   AlphaFoldDB; H2T3A0; -.
DR   Ensembl; ENSTRUT00000019216.3; ENSTRUP00000019138.3; ENSTRUG00000007706.3.
DR   GeneID; 101071290; -.
DR   KEGG; tru:101071290; -.
DR   CTD; 51013; -.
DR   eggNOG; KOG3409; Eukaryota.
DR   GeneTree; ENSGT00390000015287; -.
DR   HOGENOM; CLU_067135_3_0_1; -.
DR   OrthoDB; 297439at2759; -.
DR   TreeFam; TF316607; -.
DR   Proteomes; UP000005226; Chromosome 17.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd05791; S1_CSL4; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR039771; Csl4.
DR   InterPro; IPR019495; EXOSC1_C.
DR   InterPro; IPR025721; Exosome_cplx_N_dom.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR003029; S1_domain.
DR   PANTHER; PTHR12686; 3'-5' EXORIBONUCLEASE CSL4-RELATED; 1.
DR   PANTHER; PTHR12686:SF8; EXOSOME COMPLEX COMPONENT CSL4; 1.
DR   Pfam; PF14382; ECR1_N; 1.
DR   Pfam; PF10447; EXOSC1; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF110324; Ribosomal L27 protein-like; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Exosome {ECO:0000256|ARBA:ARBA00022835};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT   DOMAIN          64..145
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000259|SMART:SM00316"
SQ   SEQUENCE   193 AA;  21071 MW;  85245F74DEB27B85 CRC64;
     MSAKVCIPGE KLCSAEDCVL GTGVYLRHGY IHSSLAGYVV RKSEGKELPM ISVVRGTELQ
     LLPDVGAIVT CKVTSINPRF AKVHILKVGS TSLKDHFKGT IRKEDVRATE KDKVEIYKSF
     RPGDIVLAKV MSLGNVESSY LLTTAENELG VVVAHSESGA VMVPISWSEM QCPLTYAKEL
     RKVARVQAKH LEA
//