ID H2T5G1_TAKRU Unreviewed; 805 AA.
AC H2T5G1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Inner centromere protein ARK-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000019900.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000019900.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000019900.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Midbody
CC {ECO:0000256|ARBA:ARBA00004214}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the INCENP family.
CC {ECO:0000256|ARBA:ARBA00010042}.
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DR AlphaFoldDB; H2T5G1; -.
DR Ensembl; ENSTRUT00000019981.3; ENSTRUP00000019900.3; ENSTRUG00000007995.3.
DR eggNOG; KOG4456; Eukaryota.
DR GeneTree; ENSGT00730000111073; -.
DR InParanoid; H2T5G1; -.
DR OMA; SNDYGMD; -.
DR TreeFam; TF101172; -.
DR Proteomes; UP000005226; Chromosome 9.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.3600; -; 1.
DR Gene3D; 6.10.250.2990; -; 1.
DR InterPro; IPR022006; INCENP_N.
DR InterPro; IPR005635; Inner_centromere_prot_ARK-bd.
DR PANTHER; PTHR13142; INNER CENTROMERE PROTEIN; 1.
DR PANTHER; PTHR13142:SF1; INNER CENTROMERE PROTEIN; 1.
DR Pfam; PF03941; INCENP_ARK-bind; 1.
DR Pfam; PF12178; INCENP_N; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 6..41
FT /note="Chromosome passenger complex (CPC) protein INCENP N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12178"
FT DOMAIN 725..781
FT /note="Inner centromere protein ARK-binding"
FT /evidence="ECO:0000259|Pfam:PF03941"
FT REGION 48..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 483..616
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 71..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 805 AA; 92975 MW; 3D46264B5AC037DB CRC64;
MNPVLSSVQS MREMFVGKMQ DFIDEIKNVH VVWLEEIQQE ANRMFSRDFN TEPELMPKTP
SQKKNSRRKR VSVGRHEENQ TRRRFSKGRR SNLRGSSVKS LNFIAEEECV PEASRPKRTT
RKKKQTMFEE TEDVSQVPKT EETENEKPVG EQEKDEGEDN PDSAQPPPEL PAPEVAPSAS
ADQSLPDPPA PEVTVSISST DRLSAENAKI LVCSPGRTAT KVAIAEVAQS SRRSSVQCSL
KLRHSLAGLR HSMTQESVRR ASRRSMLKRK VARATSSQCS SNNEGEAEEP VDLPVRRVTR
SVAANSPKLA LPSLYSAEQK MSTPNRKTGT QSSRQSTKRK APDTAEESPT KRFSPPKKSQ
SVRPNMRSFL HTVQKNQMLM MTPNTLGRTG VIKSFIKHTT PLRIDPKTKE RYKLEALKKK
QEQEEERMKK MEEEKKRKQE ELKRSKLEAE KRGRKKEEGT RTQPLFLHVQ HQAGQMCQIW
FYLQRLAEEK AKKKAAVKRQ EELEKKKLEE EARKKKMEEE KRQLELLAKK KAEEEELARK
LAEARRALEL RREQEHERER QLERERQLER ERERVEKEKS LALQRELERA AREKERRELE
EKRKALEERR KLVKLKRMSA RETQRKWVLR VSDWDVNGLP PVEMSTAALC IYLCHCCLIR
CRYHRDKTLL SPSLPQRSVL STPVGKGIGL NVTVDMEKSP QSYVITPKGG NKPVLSKTAE
DYGMDQNSDD STDDESAPRK PIPSWAENHN LNQIIMKQYF NPPDLDSLFG VIEPPKLEDI
FYKSKPRYFK RTSSAVWHLP PTLSK
//
