ID H2T9X4_TAKRU Unreviewed; 501 AA.
AC H2T9X4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Cytochrome P450 2K1-like {ECO:0000313|Ensembl:ENSTRUP00000021464.3};
GN Name=LOC101080189 {ECO:0000313|Ensembl:ENSTRUP00000021464.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000021464.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000021464.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000021464.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR AlphaFoldDB; H2T9X4; -.
DR STRING; 31033.ENSTRUP00000021464; -.
DR Ensembl; ENSTRUT00000021552.3; ENSTRUP00000021464.3; ENSTRUG00000008564.3.
DR GeneTree; ENSGT00940000162649; -.
DR InParanoid; H2T9X4; -.
DR OMA; NTFIMAM; -.
DR Proteomes; UP000005226; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24300:SF319; CYTOCHROME P450 2K6-RELATED; 1.
DR PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 501 AA; 57853 MW; 8C324FB57F34E7C3 CRC64;
MIEDLFESST SGFLMVAIVS LLLLQLCFSF ISREKRKDLP GPEALPLLGN LHQLDLKRLD
CHLVQLSQKY GPIFRVYLAS KKVVVLAGYT AVKQALVNQA EDFGEREIFP IFHDFNKGNG
ILFTNGDQWK EMRRFALMTL KDFGMGKRTI EEKIIEECQY LIEAFEQHQG EAFSNAQVIS
YATSNIISAI MYGRRFDYKD PTFQAMIERD HEVIHLTGSP SIQIYNIFPW LGPFLKTWRY
IMKKVEINIE STRRIIGEMK ETRNPGTCRC FVDAFLIHKE NQEESDVNAH YYHEDNLLHC
VMNLFGAGTD TTATTLQWGL LYITKYPHIQ DGVQEELRRV VGNRQVRVED RKNLPYMEAV
IHETQRMANI VPMSLPHRTS RDTSFQGYFI QKGTMVIPLL TSVLYDESQW EKPHTFNPAH
FLDDEGRFVR RDAFMPFSAG RRMCLGEGLA RMELFLFFAS LLQHFHFKPA PGVSEDSLDL
TPVVGITLNP LTHKLRAISR F
//
