ID H2TBK2_TAKRU Unreviewed; 857 AA.
AC H2TBK2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000022044.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000022044.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000022044.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; H2TBK2; -.
DR STRING; 31033.ENSTRUP00000022044; -.
DR Ensembl; ENSTRUT00000022134.3; ENSTRUP00000022044.3; ENSTRUG00000020528.2.
DR GeneTree; ENSGT01050000244874; -.
DR InParanoid; H2TBK2; -.
DR Proteomes; UP000005226; Chromosome 11.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061:SF528; C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED; 1.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..857
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025475360"
FT TRANSMEM 574..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 689..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 736..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 769..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 575..822
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 857 AA; 95687 MW; FBE6013F5D4D270E CRC64;
MQLLRLLLLA VLLGKGTPLC RLRDSAQVPE LAQDGDFVIG GIFSFRTGQD YVIDTFHFNY
REFKFAQTLI FAVEEINRNP DLLPHLKLGY KIYNTCGTMD ILRAALALVS GLENEISNEN
CTKIKTIQAI LGHSGSRPTI AFAQVVGRFH IPVISHFATC ACLSNRKEFP TFFRTIPSDF
YQSRALAKLV KHFGWTWIGA IAVDNEYGLS GIATFIQAAQ EHGVCTEYSE SFSSSGPPET
LQRIVEVVKR ATSKVIVAFM SHREIKLLAQ ELYSQNITGL QWVGSDAWIT DHSLTDSSGH
SILLGSLGFT VSKAKILGLE EHLRGLHPAQ FPTSAFMTEF WEDRFACSLN ITGSTGRRPC
SGSESLQNDT SPFTDVTELR FTNNVYKSVY VVAHALDNLM KCEKGEGPFS EGSCADPKHI
QPWQVLHYIN TVRFNTSEGE TVYFERSGDS PARYELVNIQ LTDKGTLEGR TVGIYDASLP
EDHHCVEWVC VCLFVHVLQA PVSVCTQRCL PGTHKVLQKG KPVCCFDCVP CPPGEISNST
NSIHCIKCPN LFWSNQERDA CIPKSIEFLA HKELLGTLLV LFSLLGVFLT TFMFLIFYCH
KETPIVRANN SELSFLLLFS LTLCFLCSLT FIGRPSGWSC MLRHTAFGIT FVLCISCVLG
KTMVVLMAFR ATLPGSNMLK WFGPAQQRLC VVAFTFVQVL ICILWLTISP PYPFENMEYY
NDRIILECAL GSALGFWAVL GYIGLLAMFC FILAFLARKL PNNFNEAKFI TFSMLIFCAV
WVTFIPAYVS SPGKFLVAVE IFAILASSYG LLFCIFLPKY HISAVTYEIC DQKQIPSSNE
TIKFNRNGGP SHARAQK
//
