ID H2TJW9_TAKRU Unreviewed; 406 AA.
AC H2TJW9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Sorting nexin 4 {ECO:0000313|Ensembl:ENSTRUP00000024973.3};
GN Name=SNX4 {ECO:0000313|Ensembl:ENSTRUP00000024973.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000024973.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000024973.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000024973.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; H2TJW9; -.
DR STRING; 31033.ENSTRUP00000059362; -.
DR Ensembl; ENSTRUT00000025076.3; ENSTRUP00000024973.3; ENSTRUG00000009936.3.
DR eggNOG; KOG2273; Eukaryota.
DR GeneTree; ENSGT00930000151029; -.
DR HOGENOM; CLU_057138_0_0_1; -.
DR TreeFam; TF328543; -.
DR Proteomes; UP000005226; Chromosome 18.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd07622; BAR_SNX4; 1.
DR CDD; cd06864; PX_SNX4; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR034902; PX_SNX4.
DR InterPro; IPR034783; SNX4.
DR InterPro; IPR037430; SNX4_BAR.
DR PANTHER; PTHR46596; SORTING NEXIN-4; 1.
DR PANTHER; PTHR46596:SF1; SORTING NEXIN-4; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 18..145
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 406 AA; 47320 MW; EE4C383AE33F7EBC CRC64;
MVQMLDEGSG LLGRMEICIA EAEKRSGKNA MSMQETFTVY LIETRLTDAA ADGRSPAPNF
LWRRYSEFEL LRSYLTVTYP YIVVPPLPEK RAEFVWHKLS ADNMDPDFVE RRRVGLENFL
LRVALHPVLS DDRILHRFLT EHGTVEKRPI FTAVQADSRL RALNASFRVR NPEKCFLEMK
HYSDQLQSNT AQLLRARARV ADRLYGVYKV HGNYGRVFSE WSAIEKEMGD GLQSAGHHMD
AYAASIDDIL EEEEHYADQI KEYLFYSEAL RAVCRKHELT QFELEMSSQD LVCKKQQREE
LATGIVRTFS LKGMTHKLFG HEAPEQKEAR LRLLEEMIEE GEETVRVKTA EWREHVDKAC
EEMRRFKEQT DRDLREALVN YAVMQISMCK KGIQVWSNTK ECFLKM
//
