ID   H2TNE1_TAKRU            Unreviewed;       714 AA.
AC   H2TNE1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Rhotekin-2-like {ECO:0000313|Ensembl:ENSTRUP00000026197.3};
GN   Name=LOC101061851 {ECO:0000313|Ensembl:ENSTRUP00000026197.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000026197.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000026197.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000026197.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H2TNE1; -.
DR   STRING; 31033.ENSTRUP00000026197; -.
DR   Ensembl; ENSTRUT00000026304.3; ENSTRUP00000026197.3; ENSTRUG00000010402.3.
DR   GeneTree; ENSGT00940000157470; -.
DR   HOGENOM; CLU_025066_1_0_1; -.
DR   InParanoid; H2TNE1; -.
DR   OMA; TDLCFEN; -.
DR   OrthoDB; 5393023at2759; -.
DR   Proteomes; UP000005226; Chromosome 4.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd13249; PH_rhotekin2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR012966; AHD.
DR   InterPro; IPR011072; HR1_rho-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR21538; ANILLIN/RHOTEKIN RTKN; 1.
DR   PANTHER; PTHR21538:SF21; RHOTEKIN-2; 1.
DR   Pfam; PF08174; Anillin; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS51860; REM_1; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01207};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT   DOMAIN          65..140
FT                   /note="REM-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51860"
FT   DOMAIN          343..451
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          549..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          637..714
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        549..568
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        569..606
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        700..714
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   714 AA;  79543 MW;  1179D9EEDB702184 CRC64;
     MDEPRDVQTS KRHGRPQALL SAGSAMAMEV KRKKIRQSTL FQQTESKTMK RSLSLLCDTM
     EIIEDMNLLC IRQISKKLQS TDIQEKLDFE IRMREGAYKL LLACSKREQV LNASKNLLTC
     NARIKAYLTQ LQKESEEQSM MRAARRDSAE RLSCGATIAI SGLRIPLMWR DSDHFNNRGS
     SRRVAVFCLL QIGSEVFDTR MMVVDRSVTD ICFEGTSIFK DAFPEFELRV ELWSCAVEDE
     LTLANTPKKL AKKLRSSFGR SAGKNLCPLL DSPDPDTFLQ YNPIPAGAKY SLLAYTTLGL
     PEAEGSFQSH SLVVLQNAEW SSWLPLYGNL CSKLVAQPVC MTQSMKRGYL SQKKSVEGIN
     HCCRLYCVLS AGVLSCYFTP EEIEAKVPPT LRVAIDKDTR IRVIEKESSG QKSRRLSIIN
     PSPEGSQNLT FSTESSEELD DWLDALHQHL FDQSQWLHCC NQLMKIEVVS PRKPSLFLTK
     QADSVYNDLS IISPGKFEGI TDIIHNKIVE SDGRFLIGDE QEKDVADWAT LFDGSHSLVV
     QKSLLSESKT STPYSSPISA STSNSSKKRR APPPPPSAQP YAPPTCPTRP PPPAARRPPP
     PPYQEKENCI SRPATRSKTG RPSLDAKFSA IIQQLQRNNG GGSAGHGRRN APLGVLDVPT
     PGQPQPPLQQ LELQDNEAEG EHGFVRPGHG GAPAPTPRSK LRKSFRERMN LKAL
//