ID   H2TRE1_TAKRU            Unreviewed;       593 AA.
AC   H2TRE1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=glucuronosyltransferase {ECO:0000256|ARBA:ARBA00012544};
DE            EC=2.4.1.17 {ECO:0000256|ARBA:ARBA00012544};
GN   Name=LOC101076537 {ECO:0000313|Ensembl:ENSTRUP00000027248.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000027248.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000027248.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000027248.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR   AlphaFoldDB; H2TRE1; -.
DR   Ensembl; ENSTRUT00000027357.3; ENSTRUP00000027248.3; ENSTRUG00000025427.2.
DR   eggNOG; KOG1192; Eukaryota.
DR   GeneTree; ENSGT00940000159677; -.
DR   TreeFam; TF315472; -.
DR   Proteomes; UP000005226; Chromosome 22.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR48043:SF157; UDP GLUCURONOSYLTRANSFERASE 1 FAMILY POLYPEPTIDE A3 PRECURSOR-RELATED; 1.
DR   Pfam; PF00201; UDPGT; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU003718}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        560..583
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          68..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   593 AA;  66209 MW;  7DAA2756FBBA4D6E CRC64;
     MTHEQGSFTL PGWAEKGEKE WFTHTFHHFV RAFLLELFSS RGEGTMRSAA LLVIMLLSMQ
     VKGAVDKTAG PVGGGNQRPE ETKGTTNTAN DSDPPFLGNL LVVPMDGSHW VDLKALAQEM
     GRRGHRVTVV IPEVSMRMGP GKYYDTVTFP VPYDKDLVAS LMGDNKGILE KSTVGFTEKI
     QNRISQFQTF ASFLHTTAES LLFNASIISQ LEQQNFDAVL TDPMVPAGAL IARKLGLPIV
     NLLRGIPCML DMKSAGCPSP PSYVPRYMTG YTDKMNFKER TINTMVALLE PLMCKLLFWQ
     FDYISHQFLG EEVGIAEVLS ESAVWLLRID MTLELPRPLM PNTILVGGIN CNVRDALPED
     LLPWVSGEHG FIVFTLGTAV SEMPEETTTI FLEAFRQIPQ KVIWRYTGQI DGNLPDNVKI
     MKWVPQNDLL AHPGARAFIT HAGSHGLYEG LCHAVPMVMV PLSAEQPDNA EKMASRGAGI
     VLNVLSVTTE DIVQALNNVI NDTRYKDNIK TLSELHKDQP MNPLELSVYW TEFVMRHKGA
     KHLRPAVHDL NWIQYYCLDV VAFLFTILLL LVVLTVKCLK VCLRKLGGKR KRD
//