ID   H2TRV5_TAKRU            Unreviewed;       762 AA.
AC   H2TRV5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Double-stranded RNA-specific editase B2 {ECO:0000313|Ensembl:ENSTRUP00000027412.3};
GN   Name=ADARB2 {ECO:0000313|Ensembl:ENSTRUP00000027412.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000027412.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000027412.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000027412.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H2TRV5; -.
DR   STRING; 31033.ENSTRUP00000027412; -.
DR   Ensembl; ENSTRUT00000027521.3; ENSTRUP00000027412.3; ENSTRUG00000010848.3.
DR   GeneTree; ENSGT00940000157252; -.
DR   InParanoid; H2TRV5; -.
DR   OMA; VMSHRTE; -.
DR   OrthoDB; 118472at2759; -.
DR   Proteomes; UP000005226; Chromosome 10.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd19896; DSRM_RED2_rpt1; 1.
DR   CDD; cd19899; DSRM_RED2_rpt2; 1.
DR   Gene3D; 3.30.160.20; -; 2.
DR   InterPro; IPR002466; A_deamin.
DR   InterPro; IPR044460; ADAR3_DSRM_1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   PANTHER; PTHR10910:SF17; DOUBLE-STRANDED RNA-SPECIFIC EDITASE B2; 1.
DR   PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR   Pfam; PF02137; A_deamin; 1.
DR   Pfam; PF00035; dsrm; 2.
DR   SMART; SM00552; ADEAMc; 1.
DR   SMART; SM00358; DSRM; 2.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR   PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR   PROSITE; PS50137; DS_RBD; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT   DOMAIN          134..200
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   DOMAIN          291..358
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   DOMAIN          430..758
FT                   /note="A to I editase"
FT                   /evidence="ECO:0000259|PROSITE:PS50141"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          52..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..35
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   762 AA;  85036 MW;  34B3350A0B6D5764 CRC64;
     MASLLGNGGR ASGAQGGQVK CKLKRRRRRR SKRKEKVGML SALIAPFKYI SPGTSSTEDE
     DSLSTSSAEV KENRNVGNLE DLTIGSAECP SLFRSDSARG GSSGLKRKRP LEEDNNSHLC
     QLRLIYKKLS WSDSPKNALV QLNELRPGLQ YRMVSQTGPV HAPIFSIAVE VNGLTFEGTG
     PTKKKAKMRA AELALKSFIQ FPNAPQAHLA MGNISNPAAD FTSDQADFPD TLFKEFESSQ
     CSDSLSICSS GKESKLLSSE LLRHGRLLRH TLDLMVQAQQ RLGGMVQEPE SPKSPVALLN
     ELRPGLRYAC LSERAEGRKL RSFVMAVRVD GRIFEGCGRS KKLAKNQAAQ CALRALFNIR
     IAPEVRTGLK ASRKGCPHLP QDFADSIFHM VREKYRSLVG GCSPAHARHK SLAGIVMTRG
     LDLRHAQVVA LSTGTKCING EYLSDHGLVV NDCHAEVTAR RALLRFLYSQ LEFFLSKRPE
     DWEESIFVRH KERGYRLRDN VHFHMYISTS PCGDGRLNSP YEITSDIHSS RHLMRKHRSH
     LRTKIESGEG TVPVRSRGPV QTWDAILQGE QLITMSCTDK ITRWNILGLQ GALLSHFVEP
     VYLHSVTIGS LRHTGHLGRV LNQRLERLGP LPTTHRRNQP LLSGLSSADY QQHGKASCVS
     INWTLGDTQV EVVNTATGRR RETGTPSRLC KHALFTRWSR LHRKLGAHAP SSCDHQLMYI
     EAKMAARPYQ TVKQQWFRSL QETGLGTWVK KPPEQEQFLL SV
//