ID H2TSE4_TAKRU Unreviewed; 706 AA.
AC H2TSE4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) {ECO:0000313|Ensembl:ENSTRUP00000027602.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000027602.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000027602.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000027602.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR AlphaFoldDB; H2TSE4; -.
DR STRING; 31033.ENSTRUP00000058344; -.
DR Ensembl; ENSTRUT00000027711.3; ENSTRUP00000027602.2; ENSTRUG00000010930.3.
DR eggNOG; KOG4637; Eukaryota.
DR GeneTree; ENSGT00940000155553; -.
DR TreeFam; TF102033; -.
DR Proteomes; UP000005226; Chromosome 21.
DR CDD; cd12924; iSH2_PIK3R1; 1.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR CDD; cd11910; SH3_PI3K_p85alpha; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR044124; ISH2_PIK3R1.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035591; PI3K_p85alpha_SH3.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..79
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 313..408
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 606..700
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 79..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 429..456
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 706 AA; 80969 MW; 6E06A5E378B76D5B CRC64;
MSSEGFQYRA LYDYKKEREE DIDLHVGDVL LVSRGALLAL GCSSGAEERP SEIGWLPGFN
ETTQEKGDFP GTYVEFIGRK RMSPPTPKPR PPRPPSASAR ADSESDGFVL PDLAEQFGPP
DTAPPLLTRL MEAIENKGTC ILADAGEEFL LPLVLYLICC DVSLLLNTGV FVFSDLEQLD
LLSLCCGVLR FLQDLPGPIL PSILQADMIR AVQGEIWSLA APVLIYLVKP LCPFLLLSQR
IWAWQLPLAD RAVTDLTHAG DVSSRMMFLL ISQMNQLLFP LFSPALPPKP VKCSTPAPPS
SFNNSISLQD AEWYWGDISR EEVNEKLRDT ADGTFLVRDA STKMHGDYTL TLRKGGNNKL
IKIFHREGKY GFSDPLTFSS VVELINHYRH ESLAQYNPKL DVKLLYPVSK HQQDQVVKED
SIEAVGKKLH EYHLQYQEKN REYDRLYEEY TRTSQEIQMK RTAIEAFNET IKIFEEQCQT
QERFSKEYID KFRREGNDKE IQRIMENYDK LKSRISEIVD SKRHLEVDLK KQAADYREID
KKMNSIKPDL IQLRKTRDQY LMWLTQKGVR QRKLNEWLGL KNETTEDEYS MVEDEEDLPH
HDERLWRLGN INRTQAESLL RGKRDGTFLV RDSSKAGCYA CSVVVDGEVK HCVINKTSTG
FGFAEPYNLY ASLKELVLHY QHTSLFQHND SLNVTLAFPV YSQQRR
//
