ID H2U0S7_TAKRU Unreviewed; 322 AA.
AC H2U0S7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=TAR DNA binding protein {ECO:0000313|Ensembl:ENSTRUP00000030537.3};
GN Name=tardbp {ECO:0000313|Ensembl:ENSTRUP00000030537.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000030537.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000030537.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000030537.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; H2U0S7; -.
DR Ensembl; ENSTRUT00000030654.3; ENSTRUP00000030537.3; ENSTRUG00000012070.3.
DR eggNOG; ENOG502QPQ8; Eukaryota.
DR GeneTree; ENSGT00940000154343; -.
DR HOGENOM; CLU_012062_6_1_1; -.
DR InParanoid; H2U0S7; -.
DR OMA; WGSASNP; -.
DR TreeFam; TF315657; -.
DR Proteomes; UP000005226; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR GO; GO:0048514; P:blood vessel morphogenesis; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0007528; P:neuromuscular junction development; IEA:Ensembl.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR CDD; cd19609; NTD_TDP-43; 1.
DR CDD; cd12321; RRM1_TDP43; 1.
DR CDD; cd12322; RRM2_TDP43; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR041105; TDP43_N.
DR PANTHER; PTHR48033; RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN; 1.
DR PANTHER; PTHR48033:SF9; TAR DNA-BINDING PROTEIN 43; 1.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF18694; TDP43_N; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 121..213
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 204..275
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 322 AA; 36114 MW; 070EE572F7B61F2D CRC64;
MPYLYIRVAE DENEEPMEIP SEDDGTVLLS SVAAQFPGAC GLRYRNPETQ CLRGVRLLEG
VLYAPENDWG NLVYIVNYPK VSPTSDASEA ASIYVSDNKR KMEEIDAASA VKVKRGFQKT
SDLIVLGLPW KTTEQDLKDY FSTFGEVIMV QVKRDLKTGN SKGFGFVRFT DYETQIKVIA
QRHLIDGRWC DCKLPNSKAC PDDRKVFVGR CTEDMTAEEL RQYFMQYGEV TDVFIPKPFR
AFAFVTFADH QVAQALCGED LIIKGVSVHI SNAEPKHNNS RQMTEGGQSG AVHQAFPNFP
GGMATLAAMF NRSQYQFPSS HV
//
