ID H2U176_TAKRU Unreviewed; 398 AA.
AC H2U176;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000030687.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000030687.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000030687.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GAB family. {ECO:0000256|ARBA:ARBA00029462}.
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DR AlphaFoldDB; H2U176; -.
DR STRING; 31033.ENSTRUP00000084070; -.
DR Ensembl; ENSTRUT00000030804.3; ENSTRUP00000030687.3; ENSTRUG00000024861.2.
DR GeneTree; ENSGT00940000159803; -.
DR HOGENOM; CLU_028652_0_0_1; -.
DR Proteomes; UP000005226; Chromosome 15.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046355; Gab1-4-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45960; GRB2-ASSOCIATED-BINDING PROTEIN; 1.
DR PANTHER; PTHR45960:SF3; GRB2-ASSOCIATED-BINDING PROTEIN 3; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 5..117
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 278..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 45040 MW; 39F89C72AE7CA067 CRC64;
MSAGDVVCTG WLIKSPPEKK LKRFAWRKRW FVLRRGRMSG NPDVLEYYQT KNSKKPIRII
DLKECEVETL SVQLRIKRDF HGKHLFVVKT SSRIFYLVAK TEEEMNDWIN NISQICHFGS
LDDAGKKKEN INIKPAFKEI GTKVSGRASV SSQLDSSHPL DYLFLSECET GSVSVSGCFR
SCPICRHDSF SNSEISLEQK STDDATKDTV PSPLYTNSSS LFLSHTSPGP GLFLHGSLTN
PPFSAPCASM VLPSSSSSPL HHCATSVFQF DKPFSPASFE ERDERQTPPP LPPKPSHPSE
RQKDGSDGSC RTIITQTFSS HAALFPRRTS LSSLDRYRIG LLQFMLIYYM IKQHVFPSTQ
KPFLSDEHRV DYVQVDEKKT QALQNTKMEW TDVRQSKT
//
