ID H2U300_TAKRU Unreviewed; 378 AA.
AC H2U300;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Probable G-protein coupled receptor 34 {ECO:0000313|Ensembl:ENSTRUP00000031311.2};
GN Name=GPR34 {ECO:0000313|Ensembl:ENSTRUP00000031311.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000031311.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000031311.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000031311.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR AlphaFoldDB; H2U300; -.
DR STRING; 31033.ENSTRUP00000031311; -.
DR Ensembl; ENSTRUT00000031433.3; ENSTRUP00000031311.2; ENSTRUG00000012365.3.
DR eggNOG; ENOG502QT81; Eukaryota.
DR GeneTree; ENSGT01060000248589; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; H2U300; -.
DR OMA; CKLVGNL; -.
DR OrthoDB; 3875139at2759; -.
DR TreeFam; TF330969; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24233:SF1; G-PROTEIN COUPLED RECEPTOR 34-RELATED; 1.
DR PANTHER; PTHR24233; P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..313
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 42717 MW; 8309696CBD93B386 CRC64;
MSSSSSSATS LPPPSTPSHT NHSHQCMEDP NLRLPLAAMY SLFFVFGLVG NLAALWVFLF
QRSSNNSLRL FLINCAVADL VLLGCLPFRI SYHLNGDQWH LGPLACKMVG NLFYMNMYIS
IMLLGFISLH RYLRIKGKGR ARQGITVKLL GHRCPWSWVA CGTLWSLSLV GLVPMIVMAE
DEEHSNKCFQ FKMRSGNGKG KAIFNVLVVV FFWLVFIMLV VSYVKIASKL LRVSWDKPDL
PNAHRYQRSA KKSFFVLFLF IVCFGPYHAF RPVYIFYQIK NNQPCEILQT VARTNEIMLL
LSAFNSCLDP VMYFILSGSV RKSTLRAVGH RLGNHLLFLQ DASSTTESRR PSGPVVLPNT
PSVTHRTSMI NNATLRRN
//
