ID H2U5H1_TAKRU Unreviewed; 639 AA.
AC H2U5H1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=TATA-box binding protein associated factor 6 like {ECO:0000313|Ensembl:ENSTRUP00000032187.2};
GN Name=taf6l {ECO:0000313|Ensembl:ENSTRUP00000032187.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000032187.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000032187.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000032187.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TAF6 family.
CC {ECO:0000256|ARBA:ARBA00007688}.
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DR RefSeq; XP_003966840.1; XM_003966791.2.
DR AlphaFoldDB; H2U5H1; -.
DR STRING; 31033.ENSTRUP00000032187; -.
DR Ensembl; ENSTRUT00000032311.3; ENSTRUP00000032187.2; ENSTRUG00000012717.3.
DR GeneID; 101074859; -.
DR KEGG; tru:101074859; -.
DR CTD; 10629; -.
DR GeneTree; ENSGT00640000091486; -.
DR HOGENOM; CLU_022764_0_0_1; -.
DR InParanoid; H2U5H1; -.
DR OMA; YYQHVTR; -.
DR OrthoDB; 3014558at2759; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0000124; C:SAGA complex; IEA:InterPro.
DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:InterPro.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd08050; TAF6C; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 1.25.40.770; TAF6, C-terminal HEAT repeat domain; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037796; TAF6.
DR InterPro; IPR011442; TAF6_C.
DR InterPro; IPR046344; TAF6_C_sf.
DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR PANTHER; PTHR10221:SF22; TAF6-LIKE RNA POLYMERASE II P300_CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L; 1.
DR PANTHER; PTHR10221; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6; 1.
DR Pfam; PF02969; TAF; 1.
DR Pfam; PF07571; TAF6_C; 1.
DR SMART; SM00803; TAF; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 10..73
FT /note="TATA box binding protein associated factor (TAF)
FT histone-like fold"
FT /evidence="ECO:0000259|SMART:SM00803"
FT REGION 500..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 639 AA; 69821 MW; 6E542DF3A23BB063 CRC64;
MNDRDERRFA EVSHESVRLM AESAGVELDD DVAALLAEDV CYRLREATQS SSQFMKHAKR
RKLTVEDFNR ALRWSNVEAI FGCGAQDATP FRSLKDGELF LVEDRDVNLV ELALATNIPK
GCAETVVRVN VSYLDGKGNL ESQGTVPTAV QSLSDELMKY YQQVTRAILG DDPHLMKVAL
LDLQSNSKIA ALLPYFVYVI SGVKSVSHDL EQLNRLLHMV KSLVRNPYLY LGSYVRSLVS
SVMYCILEPL AASINPLNDH WTLRDYAALL LSHIFWIHGD LVGGLYHQVL LSLQKVLSDP
VRPLCSHYGA VVGLHALGWK AVERVLFPHL PAYWANLQAV LDDNSVSNAQ VKADGHKVYG
AILVAVEQLL KLKALSQPAE GAHTGPLGSV LGATAYNMRS PGLSPPPESL SDAASGIASH
LQAGGACCPW EEWTPVSLPA MYSELYSFFG DSLAVRFSTG SGFGSCPPCT LFQLNDAKKE
LPSSASNSET TRKMPQLTAN LNISPSQDGS PCPDSQLPSL TAAGSARSLA RSSSSSVQRS
RSYTSRSGQH SAGPPRDIFP KACFTSNQIG HPGFSFLIGG RQMGRRCQGR RPFQTTFTPT
LPFSAIPPRV FAHKLPVIGR VGKPVRHWTR SHYSLHLPL
//
