ID H2UF78_TAKRU Unreviewed; 1285 AA.
AC H2UF78;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Lysine demethylase 2A {ECO:0000313|Ensembl:ENSTRUP00000035597.2};
GN Name=KDM2A {ECO:0000313|Ensembl:ENSTRUP00000035597.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000035597.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000035597.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000035597.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the JHDM1 histone demethylase family. JHDM1D
CC subfamily. {ECO:0000256|ARBA:ARBA00006942}.
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DR RefSeq; XP_011608910.1; XM_011610608.1.
DR STRING; 31033.ENSTRUP00000035597; -.
DR Ensembl; ENSTRUT00000035725.3; ENSTRUP00000035597.2; ENSTRUG00000013920.3.
DR GeneID; 101067040; -.
DR KEGG; tru:101067040; -.
DR CTD; 799441; -.
DR eggNOG; KOG1633; Eukaryota.
DR eggNOG; KOG1947; Eukaryota.
DR GeneTree; ENSGT00940000155484; -.
DR InParanoid; H2UF78; -.
DR OMA; MQMPDPD; -.
DR OrthoDB; 2784357at2759; -.
DR TreeFam; TF106480; -.
DR Proteomes; UP000005226; Chromosome 14.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd22181; F-box_FBXL11; 1.
DR CDD; cd15555; PHD_KDM2A_2B; 1.
DR Gene3D; 1.20.58.1360; -; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR041070; JHD.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002857; Znf_CXXC.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23123:SF3; LYSINE-SPECIFIC DEMETHYLASE 2A; 1.
DR PANTHER; PTHR23123; PHD/F-BOX CONTAINING PROTEIN; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF17811; JHD; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF16866; PHD_4; 1.
DR Pfam; PF02008; zf-CXXC; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00367; LRR_CC; 3.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51058; ZF_CXXC; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00509}.
FT DOMAIN 146..314
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 513..561
FT /note="CXXC-type"
FT /evidence="ECO:0000259|PROSITE:PS51058"
FT DOMAIN 568..628
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 627..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..843
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..975
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1285 AA; 144393 MW; 44574B90C73622E6 CRC64;
MEDPHTRYSK RLRTGTRRRY QDDGISDDEI EGKRTFDLDE KLLCDRFNSE LIKHMKGNEF
TFEYIQREGL RDPIIFENSD GLGLQMPDPD FSVSDVNLCV GSRRIVDVMD VNTQKGIEMS
MAQWRRYYET PPSEREKLYN VISLEFSHTR LENLVKRPAS VDLVDWVDNM WPRHLKERQR
DSTNAIIDMH YPKVQKYCLM SVQGCFTDFH IDFGGTSVWY HILRGAKVFW LIPPTPQNLD
MYENWVLSGK QGDIFLGDKC YDCQRIELRQ GNTFIIPSGW IHAVYTPEDT LVFGGNFLHS
FNIPMQLNIY SIEDRTRVPA KFRYPFYYEM CWYVLERYLY CLTNVSHYTP EFQKYSLGLG
LAPTDLENYD QSGNCAPDGV NAEAGSIDVS EDVKKEEEAT AVNKPKHVLT NFEMEGLWNL
LGKLEELPDH KKCVPDGIRD PSALLNNIKA VLKQCALDDP KLSYTGEPIV KWPERPAWYQ
PPAVPPPVLY RPRLGPTLHK SHGQKRTKSS SISALRRRRV RCKRCAGCCR KECGNCIYCH
DMRKFGGPGR MKKGCIMRQC LAPALPNTAR CAICREGEFD ESDPSTYSLM ECSVCSQIAH
RQCIKEPGEG KINKDLPSCW ECPKCYQGKD SGSESSSEEE SEESEGSSFL PPSKLGNREG
IGVGEGLKKG SRNTPAARPT APPPSQKLLL QHQQSRKRAS ALELRFKKRI KLERSKVLMK
HARLDRSPRL LGSRLLSRLR SPTSTLSQGR GRGSPYNGAP GGARSFQQQQ ASHNLVLEPL
GEPRRGRGRG VRLRGGGAGR GIVRGRDLEE ESEDSSSSST SSSSSDDDEA EETGQRNGKG
LDKENQPDLS QGRATKDGEE EKMEVGNQNS GEEEEEEMET QTGGKDGSYY KVTLQKPSRA
ARDPSAIVPK LEAVTPQTAT STLHNQSRAL SRPPIRDRGP CSDQHSNRHR TSHAHSEHAV
QRSSRPERAE KTKPSRTTKL GNVGSSSSAS ELGHPRVPLS ALQEGGSEAD RENGGAGPAC
EREVWVSVFR YLSRADLCVC MAVCKNWYKW CLDKRLWSRI DLSIKRTVTP QALTGIIKRQ
PVTLDLSWTN ISRKQLNWLV GRLPGLKDLM LAGCCWSSVS ALCSSGCPLL RSLDLRYADG
VKDTQIRDLV TPPGCDNRSQ LRNMQSLRLA GLDISDSTVR LVIRHMPHLT KLDLSHCNSL
TDHSINLLTA VGSSTRNTLS ELNLGGCSKL TDTCLKYLRR LSCMSVLDLR GCKGVSRKAC
EAFISELSVN TLYCLSDEKL IQRIS
//
