ID H2UGB4_TAKRU Unreviewed; 798 AA.
AC H2UGB4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Netrin-1-like {ECO:0000313|Ensembl:ENSTRUP00000035985.3};
GN Name=LOC101070515 {ECO:0000313|Ensembl:ENSTRUP00000035985.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000035985.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000035985.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000035985.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2UGB4; -.
DR Ensembl; ENSTRUT00000036115.3; ENSTRUP00000035985.3; ENSTRUG00000014066.3.
DR eggNOG; KOG3512; Eukaryota.
DR GeneTree; ENSGT00940000166316; -.
DR InParanoid; H2UGB4; -.
DR OMA; NGYTRNH; -.
DR OrthoDB; 2916807at2759; -.
DR TreeFam; TF352481; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00055; EGF_Lam; 3.
DR CDD; cd03579; NTR_netrin-1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF444; -; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..798
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025406817"
FT DOMAIN 54..279
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 544..593
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 613..747
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT REGION 253..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 544..556
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 546..563
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 565..574
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 577..591
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 798 AA; 89613 MW; CD1B059636C5B014 CRC64;
MMFLPFSPPP SISLFPIFLL LLIFLPPSPV SSSLSHTPLS WTSPHDPCYH LDGRPRHCLS
EFINAAYGVP VNISHSLHGS DYDANVTTLT DQHNPHNLTC WMARKGSDTG EWTLTIPLGR
RFEITYISMQ FCQHREPSDP ISISILKSMD YGRSWRPMQH YSSDCLRNFG LPSQTVAKSR
HQETEPLCSD PRPLQKQRGG MVLAFSTLDG RPSSPDFDNS HTLQDWVTAT DIRVVFHRLS
KDTKAVTFRN QDQEAQWQDG TEADKGTELL QRRLGDKGRV RDQASKSNTD NTLAYFERDT
KNSEKHGKKG HYKGSGQDDG HNVTSKEGGD GFNTDVHAHS KKGGKGRGRN RKKESNQRLS
CPSGGCNWTV EGRRRNNGGR ELRKRRNNLI AKQSSRTLQM TAPAPFTPTL QAPLALSDLQ
VGGRCKCNGH ASKCRRDDNG RAVCVCEHHT AGSDCDVCED FYFDRPWHRA TPTQPNPCVA
CECNDHSNKC RFSMEVFQQS GRHSGGVCLK CRHNTAGRHC QYCQNGYTRD HSKPLEHRKA
CQPCQCHPLG AVGRWCNQTS GQCLCREGVT GLRCNRCAPG YKQGKSPLRP CIRIQEVAPT
PIFQPQYSIA EECVSYCQPS QLKVRMNLET YCLKDYVLKV QVRGMERSGP WWQFTIAVQT
VFRAGSTSRV RRGSHSLWVP DRDLRCGCPA LHVGRTFLLI GTEEGERDWG PEESRLVADR
STLALQWREH WGHKLRGFRG QDKRGRCPPK SQHGLQQTRP EPGYIPPHLL AKTNADVGST
EPPSPTTPEG IDSTRGPG
//
