ID H2UIQ4_TAKRU Unreviewed; 185 AA.
AC H2UIQ4; A0A3B5K6V4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Translocon-associated protein subunit beta {ECO:0000256|ARBA:ARBA00021110, ECO:0000256|PIRNR:PIRNR016400};
DE Short=TRAP-beta {ECO:0000256|PIRNR:PIRNR016400};
DE AltName: Full=Signal sequence receptor subunit beta {ECO:0000256|PIRNR:PIRNR016400};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000036825.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000036825.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000036825.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: TRAP proteins are part of a complex whose function is to bind
CC calcium to the ER membrane and thereby regulate the retention of ER
CC resident proteins. {ECO:0000256|ARBA:ARBA00002838,
CC ECO:0000256|PIRNR:PIRNR016400}.
CC -!- SUBUNIT: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-
CC gamma. {ECO:0000256|PIRNR:PIRNR016400}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the TRAP-beta family.
CC {ECO:0000256|ARBA:ARBA00005610, ECO:0000256|PIRNR:PIRNR016400}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003969249.1; XM_003969200.2.
DR RefSeq; XP_011607667.1; XM_011609365.1.
DR AlphaFoldDB; H2UIQ4; -.
DR Ensembl; ENSTRUT00000036957.3; ENSTRUP00000036825.3; ENSTRUG00000032227.1.
DR GeneID; 101063218; -.
DR KEGG; tru:101063218; -.
DR CTD; 6746; -.
DR eggNOG; KOG3317; Eukaryota.
DR GeneTree; ENSGT00390000005125; -.
DR HOGENOM; CLU_102025_1_0_1; -.
DR InParanoid; H2UIQ4; -.
DR OMA; ILWHSSK; -.
DR OrthoDB; 2902411at2759; -.
DR TreeFam; TF314461; -.
DR Proteomes; UP000005226; Chromosome 12.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008856; TRAP_beta.
DR PANTHER; PTHR12861:SF3; TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA; 1.
DR PANTHER; PTHR12861; TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT; 1.
DR Pfam; PF05753; TRAP_beta; 1.
DR PIRSF; PIRSF016400; TRAP_beta; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|PIRNR:PIRNR016400};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR016400};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..185
FT /note="Translocon-associated protein subunit beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025501252"
FT TRANSMEM 152..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 185 AA; 20345 MW; 0D7B066470F2B09B CRC64;
MRKEVHVFVL LALLGLSVAE EGARLLASKS LLNRYAVEGR DLTLQYNIYN VGSSAALEVE
LSDDSFPPED FGIVSGMLNV KWERIAPASN VSHTVVLRPL KAGYFNFTSA SVSYVAQEGG
EVVVGFTSAP GQGGILAQRE FDRRFSPHYL DWAAFGVMTL PSIGIPLLLW YSSKRKYDSP
KTKKN
//
