ID H2UIR5_TAKRU Unreviewed; 1725 AA.
AC H2UIR5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Pleckstrin homology domain-containing family G member 4B {ECO:0000313|Ensembl:ENSTRUP00000036836.3};
GN Name=PLEKHG4B {ECO:0000313|Ensembl:ENSTRUP00000036836.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000036836.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000036836.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000036836.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSTRUT00000036968.3; ENSTRUP00000036836.3; ENSTRUG00000014408.3.
DR eggNOG; KOG0689; Eukaryota.
DR eggNOG; KOG4240; Eukaryota.
DR GeneTree; ENSGT00940000162507; -.
DR TreeFam; TF334329; -.
DR Proteomes; UP000005226; Chromosome 7.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13242; PH_puratrophin-1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45845:SF1; PLECKSTRIN HOMOLOGY AND RHOGEF DOMAIN CONTAINING G4B; 1.
DR PANTHER; PTHR45845; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 1213..1390
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1402..1509
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 233..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1020..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1172..1214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1637..1664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1196..1214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1642..1664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1725 AA; 193398 MW; 1C7BB35297564F73 CRC64;
MLLLGKMHSR AKSRSCDNYL SIKDAESLDS CIQSTLSALY RPFGVTAATV LWQLFSVVER
QYRGDGLRCL IDFLLPSKRI LQLIQQETCV RFRGLLFYHE GWPLCIHEKV ILQLAPLHKV
RLKQGDFYLQ IVPLGRKAAK LVIKCLSASG QAITEIPITE SMYGSVFTAE FLQNVTRDRN
LHPLQNCLLT TGTAVYRTPW KNVVNPLFVS STSDTIMQAR CSRGAFRGHL STCSTSGSTG
TLDSHRSSIE SLHSQGTDSI FSEPTSPNRN PMDPNGEVHG TSDTAVPIIK LERSGEECET
GQESEDNDGR EGGPGSKMLS FTTDLSNPGC RRRPPRDSVA FESRRLFRKS YMEALQNPMS
LGSSSESILE EQSEHSIALG DRAVTPGSSP EARTPSRELL SRRLVGRGWL SSDESRPSTP
LLYLQRGLRS AERRAERRSK SLERTNKGGH VKGHRERSSS GGTVNISPKK LMNGYALRFG
KLDVEAALPG SERRTNKEES GQRGDGVSGE GRRHRLISED SHSPKSANGS AITLAPVTRP
SCESSSALPK LVSEVNQELF TSGAVILPGS RDRGGRAVLQ VCARAQVWAG ESCTVNDLTC
LLGYYYSTLR KERRDQGLSV VIDGRRQQPV PALLLSLSEL QALVPNALYS VLFLVDKETV
AKPERDMNVQ TETLTSLKAL LKHIDQNQLT RDLDGTFHYD HSHWIHFRQK IEPFASSCSA
AISSLQQSID SLGNSGNLKT SKEVSEVLEQ QRHLMKKVLD DTQLNRLRLE GGTVLARIRK
EEACENENYK DAIDMLSALY NQVDEEVHKL VILSNKCQKE LESLLEVRMF EEQTQQIKVW
FSSEGEKQLV PLESQTLSVA KIKEMRASLE HFLEESVHQQ RHGLQLVKES PESLPGSALM
DFKQHLGSIL SRVEKRKDHL EILTNLYEFY DSVNKWMEHC QDYFHQLSLD STSLILSPSV
EQTLQDYYAE ASKFSMDNFS TLNNMVLSLE SPQQLQHWNS VWHKCQQTKQ QLEEILARAT
TAQDPTATDV KTPESGASKP EQHGANACVL LPFEDSKPHS SEPYSKSPTS SISSSSHFIF
PSDCDSKLRQ SPSMFEDTDS DCTVDSSVSC HSEPIYTGTA RLRKHPMKKI MKKTVSYELN
ARDSVHSDAG HIHGYTGVYI KGLEVTNNVS AEKKLQRPDV TSPALGRSRS MSTPSRAHSR
HSDGDIKKQS SSKVQHIMDE MISTEREYVR SLSYIIEQYF PEMERLDLPQ DLRGKRSIIF
GNVEKLWDFH TQYFLKDLES CAHCPLSISS CFLRHEDQFG MYALYSKNKP QSDALLSSHG
NEFFKNKQIE LGDKMDLASY LLKPIQRMSK YALLLKDLIK ECSQSQEQEL SDLRTAEDMV
KFQLRHGNDL LAMDAIRGCD VNLKEQGQLC CQDEFIVWCG RRKYLRHVFL FEDLILFSKT
KKIEGGYDIY IYKQSFKTAE IGMTENVGDS GLRFEIWFRR RKSQDTFILQ ASSAEVKAVW
TAIIGKILWR QALRNRALRM QEMVSMGIGS KPFMDIKPSD AAISDRAIDY IMKGTEARTR
ASIAVPSFEH ATSFKRPHST ISNSSTSSSS SQSSSSLLGS LNLHLYSSPS LPHTHPYPMT
NIPSFAQWPY DCIEEDELEQ DSGSQPSMTT ESSETSSQCT SSDSVTGLST LTIAVHPSIT
MDSFNNNESS SFLCSSTPSS TMASPLMFQK EEDLQPNGTN FITAL
//
