ID H2UL40_TAKRU Unreviewed; 539 AA.
AC H2UL40;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Lactase-like b {ECO:0000313|Ensembl:ENSTRUP00000037661.2};
GN Name=LCTL {ECO:0000313|Ensembl:ENSTRUP00000037661.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000037661.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000037661.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000037661.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 1 family.
CC {ECO:0000256|RuleBase:RU003690}.
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DR AlphaFoldDB; H2UL40; -.
DR STRING; 31033.ENSTRUP00000037661; -.
DR Ensembl; ENSTRUT00000037796.3; ENSTRUP00000037661.2; ENSTRUG00000014732.3.
DR eggNOG; KOG0626; Eukaryota.
DR GeneTree; ENSGT00940000157369; -.
DR HOGENOM; CLU_001859_1_3_1; -.
DR InParanoid; H2UL40; -.
DR OMA; HGSNDFY; -.
DR TreeFam; TF314803; -.
DR Proteomes; UP000005226; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR InterPro; IPR001360; Glyco_hydro_1.
DR InterPro; IPR018120; Glyco_hydro_1_AS.
DR InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR PANTHER; PTHR10353:SF335; LACTASE-LIKE PROTEIN; 1.
DR Pfam; PF00232; Glyco_hydro_1; 2.
DR PRINTS; PR00131; GLHYDRLASE1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR PROSITE; PS00572; GLYCOSYL_HYDROL_F1_1; 1.
DR PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU004468};
KW Hydrolase {ECO:0000256|RuleBase:RU004468};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..539
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017358117"
FT TRANSMEM 514..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 383
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
SQ SEQUENCE 539 AA; 61961 MW; 7243140F6E963BFD CRC64;
MLPRRARTVG HVLVLVLCLS SAEDFDWTKN DHGSFYYGTF PTGFSWGAGS SAYQTEGAWD
KDGKGLSIWD VFSHKKGKVQ HNGTGDAACE GYYKIKDDVS LMKELKLTHY RFSISWPRIL
PTADHINEKG IQYYDDLINH LLENKITPVV TLYHWDLPQV QFKHGQLFQR LCQPSVAVEG
YETGEHAPGL KLRGTGAYRA AHHIIKAHAK VWHSYDMQWR GKQKGLVGIS LGGDWGEPVD
ISNQKDIEAA ERYVQFYLGW FATPIFHGDY PQVMKDFIGR KSVQQGLGTS RLPTFSPQEK
SYIKGTCDFL GIGHYTTRYI TQKNNPSSRG SSSYFTDRDL AELVDPRWPD PGSEWLYSVP
WGFRRLLNFV KSQYGNPMIY VTENGVSEKM ACTELCDEWR IHYHKDYINE MLKAIKDGVN
VRGYTAWSLL DKFEWDEGYS ERFGLYYVDF RNKNKPRYPK ASVQFYKRVI SSNGFPNQRE
VENWRRKAIE TCSSSNQLLA ADPLTSHMEM VTEIVVPTVC TLSILLSAVF LMFLLRRRD
//
