ID H2V0X5_TAKRU Unreviewed; 1004 AA.
AC H2V0X5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Integrin subunit alpha 11 {ECO:0000313|Ensembl:ENSTRUP00000042855.3};
GN Name=itga11 {ECO:0000313|Ensembl:ENSTRUP00000042855.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000042855.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000042855.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000042855.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; H2V0X5; -.
DR Ensembl; ENSTRUT00000043000.3; ENSTRUP00000042855.3; ENSTRUG00000016742.3.
DR GeneTree; ENSGT00940000155465; -.
DR Proteomes; UP000005226; Chromosome 13.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF21; INTEGRIN ALPHA-11; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REPEAT 7..66
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 147..328
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 338..389
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 449..510
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 512..570
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 574..634
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1004 AA; 111682 MW; 8EC1B5B91671AB55 CRC64;
GDLNYKLFTH KIIKGPKQAQ FGYTVQQHVA AGGEKWLLVG APYEMNGPHQ TGDVYKCSIN
RRNNGCSKLN LGRISLTNVS ERKDKMRLGM TLTSNPVDNS FVACGPLWSY ECGSSYYSTG
ICSRVNASFK FSRTIAPAFQ RCETYMDIVI VLDGSNSIYP WYEVQAFLIN ILQKFYIGPG
QIQVGVLQYG EKVVHEFKLS DYKSVEEVVK RARSINQRGG EETNTALGIN VARSQAFKHG
GRRGAKKVMI VITDGESHDS ADLQQVIKDC EKDGITRYAI AVLGYYNRRG INPEAFLNEI
KYIASDPDDK HFFNVTDEAA LKDIVDALGE RIFSLEGTSK NGTAFGLQMS QAGFSAHNVE
DGILVGAVGA YDWNGGVLKE TRQGKVVPPK SSYSLEFPEE LKNHGAYLGY TVTSVVSARN
GRLIVAGAPR FNHTGKVIIF TLKNSGELTI LHSLKGQQIG SYYGSEIAPV DIDGDGITDN
LLVAAPMFFS GGLEKGKVYI YRLTELNRFI LEGALEIHNG GQNARFGSAL APVPDVNGDG
FNDLVVGAPL EDDHKGAIYV FFSQQSRILR KYKQRIAAAD LAPGLQYFGR SIHGTMDMNN
DGSVDLAVGS LGAVVLLWSR SVIRIYTTVR FEPSKINIFV KDCQRGGKDV TCMSAILLPL
ATTTLGIKYN VSIAERRFNP RAVLDNPAKL QPQNLTLLPG VETCKHIYFH VMETTDYARP
IVFVVQVGLQ GSDHGPVLDD SWPTVMRTEL PFWNGCDEDE RCMPDLALQS TTDLMTRKSE
GLWRIIEGNR RRMVVDVRLE NKGENAYSAR LNITYTPNLR FSSLIVKDTS DIKIDCYAEI
KPRNEKICNV SAPFMRAKSQ VSFRLEFEFS PTVVLDHVRV VLEANSDGEE TNAADNSEEI
YYSLNYEADL LFTRESHPSR YDIKSELALE EPGVIGPPFN LTFQIQNLGY FPVRDLQLNI
EIPEMSKNGN RLLQISDFYI DKVSPESLKE AYLGVFGFFF CWAG
//
