ID H2V8B5_TAKRU Unreviewed; 394 AA.
AC H2V8B5; H2V8B6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Cytoplasmic protein {ECO:0000256|PIRNR:PIRNR037874};
GN Name=NCK1 {ECO:0000313|Ensembl:ENSTRUP00000056260.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000056260.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000056260.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000056260.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037874}.
CC Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR037874}.
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DR RefSeq; XP_003968065.1; XM_003968016.2.
DR RefSeq; XP_011606253.1; XM_011607951.1.
DR RefSeq; XP_011606254.1; XM_011607952.1.
DR RefSeq; XP_011606255.1; XM_011607953.1.
DR RefSeq; XP_011606256.1; XM_011607954.1.
DR RefSeq; XP_011606257.1; XM_011607955.1.
DR AlphaFoldDB; H2V8B5; -.
DR STRING; 31033.ENSTRUP00000045455; -.
DR Ensembl; ENSTRUT00000053022.2; ENSTRUP00000056260.1; ENSTRUG00000017728.3.
DR GeneID; 101065074; -.
DR KEGG; tru:101065074; -.
DR CTD; 100334953; -.
DR eggNOG; KOG4226; Eukaryota.
DR GeneTree; ENSGT00940000156601; -.
DR HOGENOM; CLU_025160_0_1_1; -.
DR OrthoDB; 25798at2759; -.
DR Proteomes; UP000005226; Chromosome 10.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-UniRule.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:UniProtKB-UniRule.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd11900; SH3_Nck1_1; 1.
DR CDD; cd11901; SH3_Nck1_2; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR017304; NCK.
DR InterPro; IPR035562; Nck1_SH3_1.
DR InterPro; IPR035564; Nck1_SH3_2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR19969:SF16; CYTOPLASMIC PROTEIN NCK1; 1.
DR PANTHER; PTHR19969; SH2-SH3 ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR PIRSF; PIRSF037874; Cytoplasmic_NCK; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037874};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR037874};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Translation regulation {ECO:0000256|PIRNR:PIRNR037874}.
FT DOMAIN 2..61
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 109..168
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 202..264
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 297..391
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 394 AA; 43841 MW; F09EC115490F71EA CRC64;
MTEEVIVVAK FDYMAQQDQE LDIKKNERLW LLDDSKSWWR VRNATNKTGF VPSNYVERKN
SARKASIVKN LKDTLGIGKV KSRKGGMRDT ASNADTADMY ADNGERLYDL NLPAYVKFSY
AAEREDELSL VKGTRVVVME KCSDGWWRGS YNGRSGWFPS NYVTEDVDGT AGGGGTGGLG
DQTGSLTEKL AAVVNSTANG NRVLHTVQAL YPFGSDNAEE LNFDKGDVME VVEKPENDPE
WWKCRKADGQ LGLVPKNYVT VLDSVSHKQA GGSAGPPTPD CDYISPSGSG RFAGKEWYYG
KVTRHQAEVA LNQRGVEGDF LIRDSESSPH DFSISLKAQS KNKHFKVQLK ENLYCIGQRK
FHSMEELVEH YKKAPIFTSE QGDKLYLIKA LAAS
//
