ID H2VDK4_TAKRU Unreviewed; 260 AA.
AC H2VDK4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Fas ligand (TNF superfamily, member 6) {ECO:0000313|Ensembl:ENSTRUP00000047299.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000047299.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000047299.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000047299.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR AlphaFoldDB; H2VDK4; -.
DR STRING; 31033.ENSTRUP00000047299; -.
DR Ensembl; ENSTRUT00000047458.3; ENSTRUP00000047299.3; ENSTRUG00000018475.3.
DR eggNOG; ENOG502S09I; Eukaryota.
DR GeneTree; ENSGT01060000248544; -.
DR InParanoid; H2VDK4; -.
DR OMA; THIVYKK; -.
DR TreeFam; TF332169; -.
DR Proteomes; UP000005226; Chromosome 20.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0030903; P:notochord development; IEA:Ensembl.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11471:SF33; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6; 1.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 54..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 117..260
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 260 AA; 29484 MW; 9DF982F2069388F4 CRC64;
MSCDQTYPFP QVFLVDAGGS QHPDQPPGLV PCWSHPPSLE SAGRRQKSRG SMGVSPCTAL
VVLMLFLLVF AGLGFEAYEI YQMKKELRQV RWCDGHLSFS GLYEPLLKDE DDRERPAAHV
IGRIEKEKFS KTLRWESRVG RAFTSGGVSY QFQDGALQVN ETGIYHIYSR VELVFRDCSP
TSSFHHLVFV RRGGRPSPLT LMEAHRAGFC RQQSAHPWTA ESYLASALQL QTHDRVYVNV
SHPTFLSHTH YANFFGLYKI
//
