ID   H2VEQ9_TAKRU            Unreviewed;       665 AA.
AC   H2VEQ9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Inactive carboxypeptidase-like protein X2 {ECO:0000313|Ensembl:ENSTRUP00000047704.3};
GN   Name=LOC101073065 {ECO:0000313|Ensembl:ENSTRUP00000047704.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000047704.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000047704.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000047704.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the peptidase M14 family.
CC       {ECO:0000256|ARBA:ARBA00005988}.
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DR   AlphaFoldDB; H2VEQ9; -.
DR   STRING; 31033.ENSTRUP00000053781; -.
DR   Ensembl; ENSTRUT00000047866.3; ENSTRUP00000047704.3; ENSTRUG00000018622.3.
DR   eggNOG; KOG2649; Eukaryota.
DR   GeneTree; ENSGT00940000158323; -.
DR   HOGENOM; CLU_006722_4_0_1; -.
DR   TreeFam; TF315592; -.
DR   Proteomes; UP000005226; Chromosome 6.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0032101; P:regulation of response to external stimulus; IEA:UniProt.
DR   CDD; cd00057; FA58C; 1.
DR   CDD; cd11308; Peptidase_M14NE-CP-C_like; 1.
DR   Gene3D; 2.60.40.1120; Carboxypeptidase-like, regulatory domain; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR008969; CarboxyPept-like_regulatory.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000834; Peptidase_M14.
DR   PANTHER; PTHR11532:SF48; ADIPOCYTE ENHANCER-BINDING PROTEIN 1; 1.
DR   PANTHER; PTHR11532; PROTEASE M14 CARBOXYPEPTIDASE; 1.
DR   Pfam; PF13620; CarboxypepD_reg; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF00246; Peptidase_M14; 1.
DR   PRINTS; PR00765; CRBOXYPTASEA.
DR   SMART; SM00231; FA58C; 1.
DR   SMART; SM00631; Zn_pept; 1.
DR   SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR   PROSITE; PS00132; CARBOXYPEPT_ZN_1; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT   DOMAIN          49..206
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000259|PROSITE:PS50022"
SQ   SEQUENCE   665 AA;  75877 MW;  53DCB6C5F214A89D CRC64;
     MLTIPSECFL SDLFPVAAKK KEEEEERARK EKSKYLFSIL RSKHILFFQD CPPLGLESHR
     LEEDQLLASS QSRHGFSAQR GRLNMQGSEN DDDLYGGAWC AEPEETNHWF QVDARREVEF
     TGVITQGRNS ETQDDFMSSY FVAFSNDSRD WTTLHDGYAE WLFYGNVDRN TPVMNQFFTP
     MVARYLRILP QSWNGSLCLR AEVLACQLPS TYHSENEVTP TDELDFRHHN YKDMRQMMKV
     INEECPNITR IYNIGKSYQG LKMYAMEISD NPGEHETGEP EFRYTAGLHG NEALGRELLL
     LLMQFLCKEY NDGNPRVRRL VDGVRIHLVP SLNPDAYEMA FEMGSEMGNW ELGHWTEEGY
     DIFLNFPDLN SVLWGAQDRG WVPRIVPNHH IPLPENIFNT SVSLAVETKA IISWMERTPF
     VLGANLQGGE KLVAYPFDMQ RQPQSVGTPD DAMFRWLAMA YAHSHLTMTE TYRGSCHGDD
     VTTGQGIVNR ASWKPVVGSM NDFSYLHTNC FELSIFLGCD KFPHESELPL EWENNKESLL
     AFIEQVHRGI KGVVRDVEGN PLANATISVE GIWHDVKTAA GGDYWRLLNP GEYKVTAKAD
     GHTSQTRLCM VGYDSGATSC SFTLAKSNWD RIKQIMALNG TRRARRSSGS SYDWAALPFL
     FFPLV
//