ID H2XSQ5_CIOIN Unreviewed; 939 AA.
AC H2XSQ5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000032689.1, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000032689.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; EAAA01000761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2XSQ5; -.
DR STRING; 7719.ENSCINP00000032689; -.
DR Ensembl; ENSCINT00000034088.1; ENSCINP00000032689.1; ENSCING00000024899.1.
DR GeneTree; ENSGT00940000159510; -.
DR HOGENOM; CLU_003881_0_0_1; -.
DR InParanoid; H2XSQ5; -.
DR OMA; PNMINWY; -.
DR TreeFam; TF327139; -.
DR Proteomes; UP000008144; Chromosome 11.
DR GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0050839; F:cell adhesion molecule binding; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF162; LIMBIC SYSTEM-ASSOCIATED MEMBRANE PROTEIN; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 4.
DR Pfam; PF07679; I-set; 2.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 7.
DR PROSITE; PS50835; IG_LIKE; 7.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..96
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 101..196
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 210..296
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 408..503
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 510..607
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 614..696
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 705..788
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 147..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 939 AA; 103370 MW; 9EB17D74BA941108 CRC64;
RAYFFRQPSN MTVNAGDPEV IIQCHIKNFE GDVMWSKDGF AFSKPNNSPF PRYSFVQTGQ
HQGLRIVNIQ PEDDGEYNCQ ASTKFVRLRS RNARLTVLVA PQSLEISPMN SGLINVQENK
HVTIECRASD ARPTAIVTWS VGINNEEPNA HNSQATSPET KLATTTSSIT MSPTRSDNGT
ILRCFARNSA TSTPVSTEGI LNVLYAPQQP AIDTHASDTL RAGEEAIMTC TSVGGNPLPT
LIWKIGGNVI NRAFTRSGTT VTSQLRHLVR PQDHGKTVTC AASSLALYIP LTTSVTLNVH
YAPASVDIVQ HPREGAIENT TLTLSCTATK SNPPSVLTCT VGLARHRSPQ YPIYVSLKNE
GPIVENGNEL YSIFKAFNDS LKSVQTKVPL KILFPPTSVH LIMHHPKPVA GVVTNLEAGQ
TVQLLCQSQG GRPTPTLTWT KNGNPVADDG RKTRILPGTT VCREIGSNCN ILEIVLDETD
NLAEYACLAT HVASRTPKRS TMTLQVLFLA RALTVEQSPE SLASDEAVSF ICETSSSNPA
SAITWYRDGS LISTAKVEKL TTRDGRNGGM ISNSRIRFIP NYTFNGARIT CRAENPILRK
STEKSLTMNV EFSPRFAKKI FRFAATEGKR EIEIFIPVRG NPSNMTYLWS RLIPSQRNSA
IGSENEGILR IRNVHLSDAG MYQLKAINTR GESSINVLFS VYYAPRISDL SGPKTVVIGD
DVIMTCTIDS LPLTTNIPNP ERLVYDVTTK PGTSRLMIRN VTQSDRGTYR CIAANGVGTA
GTSEFKLSIK FGAVIDRRNT PIKVARPPPT GVRKRVAIVC RAFGNPDVTF QWKDNIKCIL
SHVLFRYVSE FRRHDHDLFS STLYINVAHL KGGFYVTKFT CDVTNSLGFD RTYISIVPMG
VPDTPTELRI TNHTFDAITV AWRPAFDGGK KQSFVLQYK
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