ID H2Y6J7_CIOSA Unreviewed; 2304 AA.
AC H2Y6J7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Notch {ECO:0008006|Google:ProtNLM};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000000945.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000000945.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 51511.ENSCSAVP00000000945; -.
DR Ensembl; ENSCSAVT00000000955.1; ENSCSAVP00000000945.1; ENSCSAVG00000000533.1.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00980000198606; -.
DR InParanoid; H2Y6J7; -.
DR TreeFam; TF351641; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 25.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 31.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00008; EGF; 19.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF12661; hEGF; 6.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 2.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 33.
DR SMART; SM00179; EGF_CA; 29.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 15.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF90193; Notch domain; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 20.
DR PROSITE; PS00022; EGF_1; 31.
DR PROSITE; PS01186; EGF_2; 26.
DR PROSITE; PS50026; EGF_3; 33.
DR PROSITE; PS01187; EGF_CA; 7.
DR PROSITE; PS50258; LNR; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..34
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 36..71
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 72..108
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 113..150
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 152..188
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 190..228
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 230..266
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 267..307
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 309..347
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 349..385
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 387..423
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 425..461
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 463..498
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 500..536
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 538..573
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 575..611
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 613..648
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 650..686
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 688..724
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 726..764
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 766..802
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 804..840
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 842..878
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 880..916
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 918..954
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 956..992
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1003..1040
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1042..1078
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1080..1116
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1118..1154
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1156..1194
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1196..1235
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1237..1275
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1329..1367
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1368..1406
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1801..1833
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1834..1866
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1867..1899
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1652..1673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1685..1803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1955..2010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2022..2053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2165..2185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2198..2304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1740..1766
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1784..1803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1965..1979
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1983..1998
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2207..2223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2244..2265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 24..33
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 40..50
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 61..70
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 98..107
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 140..149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 178..187
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 218..227
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 256..265
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 278..295
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 297..306
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 337..346
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 375..384
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 413..422
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 451..460
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 467..477
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 488..497
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 526..535
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 542..552
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 563..572
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 601..610
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 617..627
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 638..647
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 676..685
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 714..723
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 735..752
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 754..763
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 792..801
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 830..839
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 868..877
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 906..915
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 944..953
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 982..991
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1030..1039
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1068..1077
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1106..1115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1165..1182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1184..1193
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1225..1234
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1265..1274
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2304 AA; 246722 MW; 8CF0FE722A67FE4A CRC64;
SHCLNGGTCH TSIEAGQVVR MCACPFAYTG STCEVPISSC EEADCVNGEC EIRSGTAVCV
CEQGFTGSRC NQVDYCYTNP CKNGANCTNR PLQFVCHCTA NWFGATCQNF RSPSTPCTPD
PCVNSGTCVE KSTTEHQCVC LPGFEGVNCE IDIDDCEGDP CHNGATCIDQ ANSALCQCTD
GWTGATCDVD VDECMLNPTA CLNGGTCVNT EGSYQCTCVN GWTGDDCSEN VDDCASKPCF
FQGTCVDYVG TFKCICPPGK TGLLCHMDNA CEETPPPCAA WAQCEINPLT GTAICTCPEG
YTGVNCSLDL NECDLGTNPC EYGGTCQNLP GTYECQCAPG FTGPRCEVNI NECESNPCVN
DATCLDKIGK FLCLCMPGYT GMTCSEEINE CSANPCDYGG ECIDHINSYT CNCAAGYTGK
NCEININDCA STPCQNHIQC VDGVNDYSCV CKAGYDGKNC ENDIDDCATS PCHYGTCVDG
INRYTCNCQL GYGGSLCDSP INECDSTPCQ NGGTCHDLVA SYSCDCPLGT SGTNCEINIQ
ECASSPCQHG QCIDGINKYT CDCDPGYTGL HCEADIDECL SDPCYNGGTC INNLNSFVCH
CPAGYNDPRC YSNINECTSN PCQNGFCHDD INKYVCECNA GYEGVNCEYN IDECESKPCL
NGASCVDHVD SYSCTCRPGY KGVNCETDID ECHQSPCLNG GSCANLIGRY VCTCLLGFTG
TDCETALTPC DPQPCNNGGS CHPNADYLGY SCTCTEGFQG PTCANDINEC MTPPCKNGGK
CRNLEPGYLC DCLDGYTGTN CETNIDDCHP DPCMNGGTCL DDVNSYKCLC KRGFDGGQCQ
NDVDECASGP CQNGATCTEY VNSYACTCQP GFRGSTCNEN INECITGSCL NGGSCVDGIN
SYSCNCVAGF TGNNCERDID ECSSSPCQNG APCLHGIDTF TCQCLTGYTG PTCAQLVNLC
QPNPCNNGGQ CSQTGTTFMC VCTSGYTGVY CDVPRMSCAA AAASRGVEET QLCQHNGQCI
NRGSTHYCSC STGYVGSYCE TDFDDCASYP CKNGATCTDY PGSYTCTCVD GFVGTDCATE
LNECSSDPCL HNGQCVDLVN SYKCLCQVGT SGDRCQDNEN DCTPTSCLNS GSCVDGIGGF
TCNCVPGYAG PSENRDVNEC SPNPCNPDGS TNCIQGINTF TCTCKQGFTG GRCEKQLTSC
STMPCLNGAT CTDATYEPTG YRCTCPTGYR GTNCDEVMSK CHDGLVCYNG GTCHESSSGG
EICMCPADYN GDNCIYYIPG QPAGVGTNDI SIPNVISKQR ELQSKCNTYG CEYDGGDCSF
GIADPWDKCP QTLQCQKYFH DGMCDEACNN ADCLFDGFDC EDAQEACQSG FLEYCDRNYK
NGQCDSGCNT QGCGWDGLDC DKDRPEQLAV GELILIVLIS PEELIARQAE FMRLIGTIIH
SVVQFKLTPT GEPFIEAIPS TKVIEIDRSM FGNRTHTRLR RASDSFFSRA HLIVDTQKCK
ETSDQCVQAT DNAASLIAAR AGTNTLEATF PISTVDSSTS TTTASQDYTY IVGAAGGVVI
VIVIIAVLTH RKRKRETSTL WSPEGFMVKK QRREPIGQAD FNLKMNGGIH PGELTQLDSS
NTPFLNRWDN GSLPQKANLY HVADTPENIT FLPGSTPVTN STNRDDMETL DNRKWTPQHL
EAADLEGVRL APQSPNSPRP PLGDEDDVNA RGPDGVTPLM IASIRGGGVD AGVSDDESQH
SGDAGGNGEG TNPKNNQLNF LKRPSKPQKQ PTKLFKIPKQ TPKTPIHPKQ NQLTPHPTTN
DGTTPMILAA RLAVEGMVEE LINANADVNA VDDHGKSALH WAAAVNNVDA MTTLLRAGCN
RDAQTEREET PLFLASKEGS YEAIRILLDH YANRDITDHM DRLPRDIAQE RLHTDIVQLL
DEYNLVRSPP IPSGHMTSHM NGHALMSRDP YLASQMKPHA GKKPRRQSNR ADGKASRRVK
KTPASQGPPS SVATADSATP VVGETPPNMG LHPGMPHIGE STLSPGNNSL PSPATTYSTD
STLSPPSSMG PPSNGSFHPH LHPHPHGGIP HQFRYGDYIL GCHHSFSSMM YNAVMDPSGA
HHPSQLAAYR SLGYPEQPNN RMDSASSDQR RFVDDGIQIN RGYTLPTSHP HAGYNTVQVI
SQTQPISSAG QTPPAQSVSR NTPLSPIFAG TLQGYNNVLE KYPTPPSAHM SPSSGSENLS
PPGPHITHNP KHVLHDYSYE TPSPDSPDPW SSSSPRSNSD WSEGIRSPTD PMPGHHHQAP
HPQHQRMRVF PPQNTGAAIA GKMG
//
