ID H2Y7K9_CIOSA Unreviewed; 3121 AA.
AC H2Y7K9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000001307.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000001307.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSCSAVT00000001323.1; ENSCSAVP00000001307.1; ENSCSAVG00000000729.1.
DR GeneTree; ENSGT00940000155282; -.
DR HOGENOM; CLU_000038_0_1_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46961:SF9; DYNEIN HEAVY CHAIN, CYTOPLASMIC-LIKE PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 503..642
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1147..1295
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1998..2053
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3121 AA; 355751 MW; C1A3892F1E10B6D2 CRC64;
PNAKGIAEKT KSKVEDFKEN IPLIQSICNP GLRDRHWDKL SEVVGFPIKP DEDSTLSKYL
DMNLDAYLTQ FESISESASK EYSLEKAMEK MVSEWSEMEF NMIPYRETGT MILSSVDDIQ
MLLDDHIVKT QTMRGSPFIK PFEEEIKDWE EKLLLVQEIL DEWLKVQATW LYLEPIFSSP
DIMAQMPEEG RRFTTVDKTW RDIMKQAIVD HHVLVVVEIE KMLEKLKKSN ELLELILKGL
NEYLEKKRLY FPRFFFLSND ELLEILSETK DPTRVQPHLK KCFEGIANLE FTDVLDITHI
KSSEGEVVKL VDQISTAKAR GQVEKWLLEL EADMVTSLRK VIGDSLEAFK VEARSEWVKK
WPGQAVLCVT QKYWTDNVQK ALNTGPQVKF LNLSQISEIV FLVRGKLSKQ NRVTLGALIT
MDVHARDVLA VLVKDKIQSE NDFAWLSQLR YYWEVNFKLS AFPLVMFYIC LAYGYEYLGN
TPRLVITPLT DRCYRTLFGA LNLFLGGAPE GPAGTGKTET TKDLAKAIAK QCVVFNCSDG
LDYIALGKFF KGLASCGAWS CFDEFNRIDL EVLSVVAQQI LTIQSGIRSG QDTLLFEGTE
IKLDVTCAVF ITMNPGYAGR SELPDNLKAL FRPVAMMVPD YAMISEIMLY SCGFVNARPL
SVKIVATYRL CSEQLSSQHH YDYGMRAVKS VLTAAANLKL AYPDENEDIL MLRSIIDVNL
PKFLAHDLPL FNGITSDLFP GIKLPKPDYS HLLEAIKNQC DKLNLQMTDF FTQKILQIYE
MLIVRHGFMI VGESFGGKTS AYRILAGALT EIHEKGLMDE NKVQITVLNP KAVTMGQLYG
SFDPISHEWS DGVLAVSYRQ FASSQTPDRK WLIFDGPVDA IWIENMNTVL DDNKKLCLMS
GEIIQMSPPM SLMFEPMDLE VASPATVSRC GMIYMEPHML GWRPLLISWL SVLPRRSLNV
LKNGLHTTNH FFNLICLKLF LKLRDKILCF KMIKHILTKY CGGKVWYSSP DVFLMQPKSK
RWTNVKLWLG LRLDGIFLFS YIWSVGATTD ADSRVKFDKL LREIMDGPLS EETKNEFHII
DPVLPPSKSF SAPIPRTADV FSWKWEKWTE SIKDAAPLAK DEMFNEITIP TQDTVRYTYL
INLLVTHQVP VLLVGPTGTG KSVYINNFLA NQLDKDSYKP MNINFSAQTT AKQTQNIIMS
KLDKRRKGVF GPPLGKKTVV FVDDINMPQR EVYGAQPPIE LLRQWLDHWN WYDLTDCTMI
KLVDIQVLAA MGPPGGGRNP ITPRFLRHFN TITINVFDND AMSTIFTRIM NWHFSISFMS
LVPQIVKGTS EIYQSAAQNL LPTPAKSHYL FNLRDFSRIV GGICLSTPLS APEPNSIKRL
WFHEVLRVYY DRLVDDTDKK WLFDHLKEVV SDHFSANFHE LFKHLDFNND AEVEEDDLRS
LMFCDFTPKN ENKLYVEVEN IDKLREVVEG HLDEFNNMSK KPMNLVIFRF AIEHVSRISR
ILKQPRSHAL LVGVGGSGRQ SLTRLASHMA DYELFQVEIS KGYTSVEWRE DLKVILRKST
EGEQHGAFLF TDVQIKEESF LEDINNLLNT GEVPNLFATD EKQEIIEKMR QIDRQRDKSK
QTDGTPVALF QLFIDRCRDQ LHIILAMSPI GDAFRTRLRK FPSLVNCCTI DWFQSWPEDA
LTAVASRFLE DVEMSDEHRI GCIEMCKRFH TSTRTLSERF MNELQRHNYV TPTSYLELIN
TFKSLLGKKR TEVHKLKRRY EVGLEKLNSA ASQVADMQKE LTDLQPQLVV ASKEVDEIMV
NVERESIEVA KVEKVVKADE AVANEQASVA KGIKDECDAD LAEAIPILEA ALSALNTLTP
ADITVVKSMK NPPAPVKLTM ETICILKNIK PERIPDPSGS GKKIEDYWVP SKKVLGDMKF
LQGLQEYDKD NIPPNLMKII RQKYIPNPEF VPEKIRNAST ACGLCKWVRA MDSYDRVAKV
VAPKKIKLKG KSGAEAELKV AMDSLRKKQA ALKEVQDKLQ ILQDKLEFNK QKKADLENQV
DLCSKKLNRA TQLIESLGGE KDRWGETAHA LGITFNNLTG DVLIASGIVA YLGTFTSKFR
EDQTAEWLKN CRADGIPCTD NVTLHMVLGE PVKIRQWNIS GLPTDSFSVE NGIIISNARR
WPLMIDPQGQ ANKWIKNMER ANNLHVIKLS DSDFVRTLEN CIQFGTPVLL ENIGEELDPL
LEPLLLKQTF KQAGAICIRL GDSTIEYSHD FRFYITTKLR NPHYLPETSV KVTLLNFMIT
MEGLQDQLLG IVVARERPEL EEEKNALILQ SAENKKIVFP ILMCVSETEQ KIDTARMGYK
PISIHSAILF FCITDLANID PMYQYSLTWY VNLFVNAIDN AEKSDILEKR LEHLRNYMTY
SLYCNICRSL FEKDKLLFSI LLCVNLLRHE GIVDDNDWRF LLTGGVGLDN PHSNPATWLP
TKSWDELCRL DNLNHFQGIR KKFPAYKEQW KVIYDSSDPH NKIPPGDWSE LVEFHRMMLL
RCLRPDKMVP AMQNFITNNL GRKFIEPPPF DLPKTFADSN STSPLIFVLS PGADPMASLL
KFADDQGMSQ AGFGGPKMTS LSLGQGQGPI AMRMIDKAIK EGTWVVLQNC HLATSWMSTL
EKICEETLNP DKIHPDFRLW LTSYPSNNFP VAVLQNGVKM TNEPPKGLKS NILRSYLSDP
ISDPEFFSSC KQPVSFFVYF KKLLFGLCFF HALVQRRQFG PLGWNIPYEF NETDLRISVR
QLHMFLNQYE VNGNCLFGTF YLDFCKNLPL LAEPQVFAMH ANADITKDQN ATQELFNSIL
LTLVGAFSRT SGGGGDSNDT LVFNVAGDIL GKLPPNFDTE AALRRYPTAY KQSMNTVLVQ
EMVRFNVLTT TIRNSLVNVQ KAIKGLVVMS ADLEEVLNSV LQGKIPQMWM KKSYPSLKPL
GGYTNDFLER LHFLEHWYQN GPPPQFWVSG FFFTQAFLTG VQQNFARKYT IPIDLLGFDY
INTKLHSDDG MWSLNLDFCA YIYGLYVEGA RWDRKAKLLA ESIPKVLHDP MPKILLVPTK
KSDIPDKPSY LSPVYKTTER RGVLSTTGHS TNFVIGMTLN SDKPPEHWIG RGVALICQLD
N
//
