ID H2YFL8_CIOSA Unreviewed; 2227 AA.
AC H2YFL8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000004116.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000004116.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 51511.ENSCSAVP00000004116; -.
DR Ensembl; ENSCSAVT00000004178.1; ENSCSAVP00000004116.1; ENSCSAVG00000002422.1.
DR eggNOG; KOG2302; Eukaryota.
DR GeneTree; ENSGT00940000168093; -.
DR InParanoid; H2YFL8; -.
DR TreeFam; TF313555; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF230; CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..2227
FT /note="Ion transport domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003578572"
FT TRANSMEM 45..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..813
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 833..853
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 860..879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..957
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 969..985
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1005..1028
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1243..1262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1695..1716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1728..1747
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1792..1811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1978..1999
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2011..2032
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2044..2062
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2115..2135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2204..2226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..337
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 794..1037
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1655..1845
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1976..2226
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1333..1363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1496..1548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1333..1355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2227 AA; 254549 MW; C5EF806438CBCEE3 CRC64;
QPLTWFERVS MLVILLNCVP LGLYQPCQPK PGLPCGSPRC SILEICDHFV FAFFAIEMLI
KMLAMGVWGK LGYLGEAWNR LDFFIVLCGM MEYTLQLEDT MNFTSVRTVR VLRPLRAINR
VPNMRILVML LLDTLPMLGN VLMLCSFVFF IFGVVAVQLW EGTLRQRCFL DPNVFNITGD
IVQLHNTPFY SRGEEDLAIC SLPMDSGEFH CSDRSIITPF TVENITCSNK CKLFEVTQTC
TPMCIDWNQY MNTCKAGDSN PSLGSINFDN IMYAWVAIFQ VISLEGWVDI MYYLMDGYSF
YSFIYFILLI VIGSFFMINL CLVVIATQFS ETKQREQRLM EEQRLRFKSN DSTLASYSPP
GNCYEEMLKY ISHLYRKNKR KIKSQNIFFV FLKRKIKSNI ICAMLYTYVS FQRRWHKWQT
EKKLKRSGMG SLKREVPVRS VRKKKKSIHL HHHHHHHHHH YHIADTIDRT GDGASSKIFG
ELMDGCIICT FSGLIRTLER RDRGLAITSD ACPHTPQNFT QILPQRLMLT DGSNELVEPV
KTGKYKTTQD HFKMLSLNFK AVFDPLLIFY IVSKAHGSTF VLCSFIFNGT NDGSRFVLLT
VPIHTPSAST SLHSICGAVG IPQRTNSYRD RRPSAEVTVN DPGSVYFKPR GLDPCFQPEI
LSTKFCPEDI TVYHYNAIII QVFFIFHSLN SIGKQCFPTD ILGKNNTLPR PQSFVTSELN
CSCAEYEISN PEVFEPGVES DLDEKPPTSY RRFLCCCCDQ RETKGKCKLG QFKKKLTKIC
QDFQEQTKRV VDSSYFNRGI MIAILINTLS MGIEHHSQPD GLTEVLEISN VIFTTLFALE
MIAKIVAFGV AGYTKNLYNV FDALIVIIRF VLSCVYEFIW EIAAGTQNSG GGLSVLRTFR
LLRVLKLVRF MPALQRQLVV LMKTMDNVAT FMMLLTLFIF IFSILGMHLF GCDFCWVNQY
GRTECDRKNF DSLLWAFVTV FQILTQEDWN IVLYNGMAAT SPFASIYFIT LMTIGNYVLF
SLLVAILVEG FQAEYKIQQT FVFSESLIKK TNFYFYFSFI SQDGDDEVDD YVETSSDEDE
EVELLTRGRC PLIKVSTSKD FDEICQVSIN KNVLILGLNE SSINTISNLC LKSCCSTSVE
IQRADDDSDS EFDEPPILAE NYTKKVAKAL GITGPKNVNG NTGHARKKAQ HHMHVRIIAL
VEFSSMVLYL DDYVETSSDE DEEVELLTRG RCPLIKVSTS KGGFYFCTFF LNFYFYVNFN
WVTEIYLSRP CEFLYPSPND FLTVCSPSQE KESENWSLPV ITRTSATPLH TPTLANISQE
NSLEKSFLSA ESRGSSTDSQ TEKDANHNTP QSVKKHAILS RKPSTESQNF ESFKDNLLYF
CEMLFAKNNS SALNLQTNCR TNKGILITTK SRKNHHFITK YFLQSCLSIS SVIKFGGGSP
LSRTGSWRLR KLRKIPTDQQ SLVCSDEGRN SYYEIEEDMY SNASFENEYK EREEITKNSS
TGFQDCSNKA IPSHNQNNNN SVLTNENTTN TNEKTEITSS KSESTGNSTE SRRIFNFQVS
IFMFIVTHIP QNKMCYLMSL LHNVKDHVQT KYWLWQITSH MSYLRHNPLY NNNRCKNIIQ
QVNPPNWTYT RKEWSLYLFS PELKFRRAVQ KITEHKVFDN TILLLIFGNC ITIAMERPSL
KEGDYEREVL DCFNNIFTFV FLLELILKVI ASGFYVGPKA YLKSGWNVLD FFLVSTSLID
FIMTLAYSSG SKLLGMLRVF RLLRALRPLR VISRAPGLKL VVQTLISSLK PIGNIVLICC
AFFIIFGILG VQVLKGKFYR CVGPDLRNVT NKSNCLANPN NNWVNRRFSY QLPLNGSLKQ
VFLTIPPEWL TYTGFLSKYP QLAHLHRAIF FNEYELLEYL SSFSLILSRI RSNLATSTVH
WSMRHARGEQ RLNFRRKTLS RAKNQFSNSL SSFADNTKYY EEYGPARRAL HDVCMNKYFE
IGISIVIGIN ILTMAAEHYK QPKVLDQALK IANYFFTAVF ILEAVLKLIA LGFRRYFRDR
WNQVDMLIVI LSVVGIAVEA LMTSGDERSL LINPTIIRVM RVLRIARVLK LLKVSKGIRS
LLETVGNALP QVGNLGLLFL LLFFIFAALG VELFGTLSCD EAHPCNGLSR HASFSNFGIA
LLTLFRISTG DNWNGIMKDT IRQECDASDS CMVNCCSSSI ISPIYFVLFV MTAQFVLVNV
VVAVLMK
//
