ID H2YJG0_CIOSA Unreviewed; 1108 AA.
AC H2YJG0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=SMC hinge domain-containing protein {ECO:0000259|SMART:SM00968};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000005459.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000005459.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005231}.
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DR AlphaFoldDB; H2YJG0; -.
DR Ensembl; ENSCSAVT00000005531.1; ENSCSAVP00000005459.1; ENSCSAVG00000003260.1.
DR GeneTree; ENSGT00550000074857; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR CDD; cd03273; ABC_SMC2_euk; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR027120; Smc2_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 2.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 467..587
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 712..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 246..280
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 319..442
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 757..868
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 929..970
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 712..728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 124455 MW; 6F41A4F634740553 CRC64;
MYIKSVTVDG FKSYAQRTDI SGFDPLFNAI TGLNGSGKSN ILDSICFLLG ITNLSQVRAT
NLQDLVYKNG QAGINKATVS ITFDNSNKDQ SPMGMEAHNE ITITRQIVIG GRNKYLINGV
NAQNSRVSDL FRSVGLNVNN PHFLIMQGRV TKVMNMKPPE ILSMIEEATG TSMYESKKDS
AQRMIEKKEN KLNQINRTLD EEITPTIQKL HDERSSYLEF QKVQREVERL SRLLIAYHFL
TVERVANNAS GEIEEMNGEK EKLESEVYQL QDQYRNMGQE IDFRIFNLKI GQDSKAKLSQ
LESTLGSKEK IEAKAQSNLS NQREVINSEK RKLKGLQKSK SECESAIKSK SKALDSLQSA
CDKLESESVK LAEAYTAAEK HFQLKKTEAT YKQDLEVLKK VEKRLVEIKT QMEKLNYTEG
EEEQLKAQKH DLSTKIQKMS RLTQGLFNKF PNLQFEYRDP ESNWDHRRVK GLVADLVDVK
DVANATALEV VAGGRLYNVV VDTHETGAKL LKNGQLKRRC TIIPLNKVAA RTINKEVVTH
AKSIVGRDNV NLALSLVGMD EEIRKALEYV FGGALVCDTM ENANKVAFNP NVKTRTVTLA
GELFDPSGTL TGGARPKVTP VLAELKEIKS VQQDTSECKA LMRDYAALDV KLQEVTHVSA
KYHDLKNQST LKEREINSLK QRISDTSHGR LIASAKMQDQ CAELERKIAN APAERERELK
EAEKQMNKAG SAAEKAGHSA AAKRDPGTLV HFYPQELNTM KLEVQELEKE VNDYGEQIAR
VESSIEEAQV VYQSVKETVD VAADSVKSAK AELQQHRDHI QETSHDIQQR IKQRELVQQE
AGKANKRLQE QTNAIEKCLR ESKDASNKVT AMLEEHEWIA NEKSLFGRQS SPYDFEANPP
KEASRRLEKL KERQEKLSTS VNMRAMSLLG KAEEKYNELI KKKMIVQNDK EKIQKTIEEL
DQMKNKAVTK AYVQVNKNFG EIFSTLLPGA TAKLAPAEGS SVLAGLEFHV GFGDVWKTNL
NELSGGQRSL VALSLILAML LLKPAPIYIL DEVDAALDLS HTQNIGGMLR EHFKHSQFIV
VSLKDGMFNN ANVLFRTKFV DGVSTVAR
//
