ID H2YUJ4_CIOSA Unreviewed; 4271 AA.
AC H2YUJ4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000009004.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000009004.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR Ensembl; ENSCSAVT00000009118.1; ENSCSAVP00000009004.1; ENSCSAVG00000005324.1.
DR GeneTree; ENSGT00940000164265; -.
DR HOGENOM; CLU_000038_9_1_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF15; DYNEIN AXONEMAL HEAVY CHAIN 8; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 1604..1748
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1883..2009
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2204..2352
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 3050..3098
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3357..3384
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4271 AA; 488607 MW; CB3C28F1352793D4 CRC64;
GPLAELEHWR FLMSKFNSLL EHIKGSRCKA AINTLHAAKS KVLKLWREMD AQITDHANEA
KDNVKYLYTL EKACTPLYNS DPVNMIEVIP TLVNIISMIH NISRYYNTSQ RMTSLFIKVT
NQMVTACRKY ITDNGQRRIW DQDSSLDSFC KMQWTFHILI DCVVLYKEYV NGFQRMKVDL
QSDKALDFSE MYIFGKFDTF CKRLNKITEL LQTIETFSML SESKIEGIDG LANKFQSVVS
NTKKKPYDIL DHRKVDFDND FENFKESIYS LECQLQTFMD SCFERVQASA QALLLLKRFE
KLKIPCLQTD IKDKYALILR TFGQEIDEIK KLYQKFRDDP PIPRDMPPIA GKIMWSRQLF
RKIEEPMQAF QEFAPELLKE KDGKALVKNY NRMGKILMEF EVLYYRAWCR ETDNIKYALQ
ATLLVRHPET KQLHINYDPQ VPAMVRESLC MNKMGLEVPE VATNLLHKID DLKHTKETLE
MLLEDYDKAM ESIPSIFMPL MKQHLHQVDR AVRNGLVFIT WSSLNHKLYF HNVEKELNQL
KRVIRDVNDL KEARIDDMLN DIATTALVDL EDETTYTIVD FLNCAKDHSE SMAKYLNRKS
AHIEIAVYDL IQAFAKHSGR ADFSKYKDSV DFNEDDAFAV ECEELVEYFK TRTLEALLKC
TRQSLDLIKR RSLVREGMAP LLVSNVELAI PNVELKPNLE EAQSAINETA REIGKKLSSQ
MTLQNSFDKL QNHYKAISEH KDITKLVMML GSAMNNIREP VAENLIQFNR FQMLWEEERE
SAVKEFMSTN PLLTEFRAEI MKYIINQRVE VLPSSISVGP LQLLPANIKM SLVVETKSWK
VSLCKCLNIE YRSKMEEVFD FINEYSKRLT RPIKDLDDIR EAMNSLDTIK HEFTRIDFTV
GPVEEAYAIM QKFNVKVNPE EINKVDTLRY SWNKLLSQSN MISDKLCKVQ PQFRSDLIDK
VEKFHEDSTT FQEAYDENGP MAEGISPVEA SDRLQVYQSR FDDLWRKFQT YNAGEELFGL
QVTDYPALQR TKKELNLLQK LYGLYNAVMK SINGYFDILW SEGCVMYLTL LVYISSLIQK
ICRKLPKGLK EWQAFNELKN KIDDFNETCP LLELMSDKAM KKRHWERIEN LTGYTFDIEN
ENFQLRNIMS APLLKYKEDI EDICISAVKE KDIEAKLSVV IAEWSANVLS FSVFKARGEL
LLKGQETSEI VSMLEDSLMV LGSLLSNRYN APFKPQIQLW VQKLSNTSDI IENWLIVQNL
WVYLEAVFVG GDIAKQLPKE AKRFANIDKS WVKIMTRAHE TPNVVQCCVG DETLGQLLPH
LLEQLEQCQK SLTGYLEQKR LVFPRFFFVS DPALLEILGQ ASDSHSIQSH LLGVFENVNK
VDFHEKDYDR MMAVVSKEGE TIMLEKQVIA KGNVEIWLGD LLREQQASLH SVIRDAAIQL
ADPGFQVHPY LETAPAQVGL LALQMLWTRD AEEALSNARY DKKIMPVTNQ RFLDLLNALI
AVTTKELTKF DRIKFETLIT IHVHQRDIFN DLVKMHIKTP LDFEWLKQSR FYFNNDTDKC
LVSITDVDFS YQNEFLGCTD RLVITPLTDR CYITLGQALG MSMGGAPAGP AGTGKTETTK
DMGKALGKYV VVFNCSDQMD FRGLGRIYKG LAQSGSWGCF DEFNRIDLPV LSVAAQQIYI
VLQSKKDRKT SFVFTDGDNV SLNPEFGLFI TMNPGYAGRQ ELPENLKVQF RSVAMMVPDR
QIIMRVKLAS CGFVENIVLA QKFYTLYKLC EEQLTKQVHY DFGLRNILSV LRTLGATKRA
RPNDGEPTIV MRVLRDMNVS KLVDEDEPLF LSLINDLFPG IVLDSATYED LQAAIGLNVT
EMGIVNHPPW NLKVVQLFET QRVRHGMMVL GPSGAGKTAC VNMIMRAMTE CGEPHKEVRM
NPKITAPQMF GRLDVATNDW TDGIFSTLWR RSHRTKKGEN MWLVLDGPVD AIWIENLNSV
LDDNKTLTLA NGDRIPMAPN CKILFEVSHS HYCSDLIHSV VLLPTQVFLF SCHTFQFKSV
KIYKRNKQYW VECNKITTLP DPFHQYVKPF VMRNLKHIPP QALNVLEGLI PSKEEVGILP
QFHVERLFIF CLMWSVGATL ELADRMEAFL IDHESNLDLP KIDAGSGHTI FEFVPDANGE
WEHWSKRVVE YIYPSDSIPE YSSILVPNVD NIRTKFLIDV IAKQNKAVLL TGEQGTGKTV
LIQGYMLGFN PEIMMAKSFN FSSATEPNMF QLTIESYVDK RMGSTYGPPA GRKMTVFIDD
VNMPVINEWG DQITNEIVRQ MMEMHGMYSL EKPGDFTNIV DMQFIAAMIH PGGGRNDIPQ
RLKRQFNVFN CTLPSNASID KIFGIIGLGY FCIERGFNQD VVDIIGKLVP ATRMLWQWTK
VKMLPTPAKF HYIFNLRDLS RIWQGMLTVK HEECGEKADV ISLFKHECTR VIADRFTNED
DKVWFENSIM RAIKEEVDEG LAAMATGSEP YFVDFLRDAP EPTGEEGDDA DLDAPKIYEQ
IPTLEALSEK LLSYMAQYNE SVRGASMDLV FFKDAMTHLV KISRIIRTPR GSALLVGVGG
SGKQSLTKLA SFIAGYKPFQ ITLTRTYNAQ NLMDDLKVLY RIAGGEGKGV SFIFTDNDIK
EEGFLEYLNN ILSSGEVSGL FARDEIDEIT QGLISTMKRE FPRRPPTQEN LYEYFISRSR
DNLHIVLCFS PIGEKFRNRA LQFPGLFSGC TMDWFTRWPR DALVAVSNHF LSKVQVVCEP
EVKRQLIQTM GVFHDKVAET CVEYFDRYRR TTHVTPKSYL SFLDGYKGIY KENHALLDDL
SRKNKCLAKL LEAGESVALL SKELVVKEKD LAVASVKADK VLKEVTVSAQ AAEKVKNAVL
KVKEKAQIIV DSIAVEKSAA ETKLEAAEPA MRAAEDALNT IKAADIATVR KLAKPPHLIM
RIMDATLILF MRPVDKVQPD PERPTVKPSW GEALKLMSQS GFMQSLKNFD KDSITEETVE
LLAPYFEMED YSFENAKKVC GNVAGLLSWT KAMVSFYGIN KEVLPLKANL AKSEVKLAIA
LADLAQAQEQ LDEKQRELDE VQAKFDAAMK EKQDLLDDAE SCRRKMTAAT QLIEGLGGEK
VRWTEQSQKF KAEILELVGN VLLATGFLSY CGPFNQEFRN YMIKETWEKE LSERKIPFVS
DLNLIAMLID APTIGEWNLQ GLPGDDLSIQ NGIIVTKATR YPLLIDPQGQ GKTWIRNREK
DNQLIVTTLN HKYFRTHLED ALSQGRPLLI EDIGEELDPA LDNVLEKNFI KAGSTYKVKV
GDKEVDVMSG FQLYVTTKLP NPAYTPEVSA KTSIIDFTVT MQGLEDQLLG RVILTEKNEL
EAEKVKLMEE VTRYKRKMKE LEDNLLYKLT STQGSLVDDE SLIEMLATTK EMALEVSEKL
TIAADTEVKI NTAREEFRPV AIRGSIVYFL IVEMSMVNIM YQTSLLQFLG LFDESMAKST
KSPITSKRIN NIIEFLTYTA FRYTCRGLYE THKLLFTLLM ALKIDLRKTI IRSSEFQTFI
KGGAALDLKS VVAKPCKWIL DITWLNLVQL QKLPEFREIL NQIARNEKQW KAWFDTEAPE
EEVIPDGYSA SLDTFRKLLL IRSWCPDRIM PQARKYIGQS LGARFSEAVI LNLEETHQES
TIRVPLICLL SQGSDPTDQI STLAKKKNID CRAISMGQGQ EVHARRLVST LMQIGGWALL
QNCHLGLDFM DELLDTVQTA ENVNPAFRTW ITAEEHPKFP ITLLQSSIKF TNEPPQGVKA
GLTRTFAGIS QDQLDVNNLP QWKPLLYAIG FMHTAVQERR KFGPLGWNIP YEFNTSDHYA
TVQFLQNHLD DLDPKRGIQW STVRYMIGGE VQYGGRVTDD YDKHLLNTFA AVWFHEQMFT
DAFCFYIGYK IPTFKTTKEV SSTTYSIFNR IMILSITLTQ QHPMMIIPQV MDAIDTLPLT
DTPEVFGLHM NADITYQTNS ATAILDTILN IQPKDAGGGS GETRESVVFR QAHEMLMKLP
PDYVRSKLVK MGLLNSLNIF LKQEIARMQK VITLVRITLT DLKLAIEGTI IMSENLRDAL
DNLFDAKVPS LWRKVSWESS TIGFWFTELI ERNSQLSHWI FDGRPTCFWM TGFFNPQGFL
TAMRQEVTRM HKGWALDTVT LHNEVLKQFR EDISSSPEGV YVHGLFLDGA AWDRRNSRLQ
ESQPKVLFVP LPVVHVFAIN STAPKDPSLY VCPVYKKPCR TDLTYITPLW LKTTQKPTHW
TMRGVALLCD I
//
