ID H2YZU5_CIOSA Unreviewed; 1948 AA.
AC H2YZU5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Receptor-type tyrosine-protein phosphatase F {ECO:0000256|ARBA:ARBA00044158};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000010857.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000010857.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC {ECO:0000256|ARBA:ARBA00009580}.
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DR Ensembl; ENSCSAVT00000010988.1; ENSCSAVP00000010857.1; ENSCSAVG00000006363.1.
DR GeneTree; ENSGT00940000166904; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd14553; R-PTPc-LAR-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF7; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1948
FT /note="Receptor-type tyrosine-protein phosphatase F"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003578696"
FT TRANSMEM 1302..1323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..123
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 135..230
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 238..327
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 334..427
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 432..527
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 531..625
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 630..723
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 727..838
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 839..940
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 954..1049
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1061..1146
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1394..1649
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1569..1640
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1681..1939
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1858..1930
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1948 AA; 218205 MW; 2CCBBEC0510E33C0 CRC64;
MVFCSLNILL QTLLFHLMTS TANPRSSTVA PVITNAPESQ TGVAKGTLAL ICNATGNPRP
RIDWRKDNKE ISKNRYRIVP YVFESGSGSV LWIAPARKKK DKARYTCVAS NRLGDVSESA
DVHFYDEEAT PSGFPHIDIN PTVKTVERSR AVSMECGISG SPTPSIRWFR NYQPLYLNGT
RIRMDPITVN KTTFPGSLII STSNDTDNGK YHCSGTNVHG TVFSKGTSIY VKERIVYPRF
SIPPRKSYDV KINDPFNLTC VAVGSPMPVV KWQKQTSGGL VDVWPLKGMP PIVGMNVYHM
QRVTESANYT CVAKSRISTI TTTTEVTVKS VPKAPTNVHQ YSDATSTTLS VAWDSGDLPP
ATVTGYTVFY RVMGSTTPYQ YIDQISSESF TITGLQPYTE YDVVLMASNA QGQGNTTQPV
YLRTAEAAPR SAPREVGAYL YQTNTIMVTW LEPQHPNGVI SSYNVYYTSN PSLPVSEWMD
VPVRNDRRLT ALRRLVPHVT YSIRVSATNG AGESPYSDIA VVKTTHGVPP QPRNFHGEAA
STTSIHLTWD RPNWGGASSF DITSYMVFYN CSSPSCSSQI TFEPVKEFTL GRLRPNTRYD
IRLAAQTVHG VGAETSMISV STLSDVPSAP PEHLVVSPID ATSIRVTWEP PAKESRNGEL
THYTVYYRQH GLESAAADMQ VNGTSVVVQG LQPYTEYDVW LTASTTVGEG PRANAVVTTS
QSTPAAPPSD VDLQALNSSA VRVRWSPLPT HHRNGDIRGY QIAYAISDVI TGRTLFRTVY
NEGRRENILV TYNPTQPPQE STITKLRPKT RYSVSVSAFT VRGAGPASPP KYVTTLGEVP
NAPRLEARRA DNGKAQLRWS SPVLPKGRIT GYALRYRCQE EGANAMCPWK TRLFDHNVEQ
FTPEDVIPGW TYQFFLSASN SDGPGVEASA QINLPPIAPS DAPANLSATT VLDVPGKDGS
SPPTPYALNI TWSPLTRTQS NGRILEYALY WSPSTIGSSQ PERLLTNRTY YWFINVLPNQ
KYEFNVAAVN SAGEGDRSPG LIVTVTPPLH PTDPRRKSNI TISDLGLAEV STTTVWLRWL
PPSGIDVDSY KVSVNANVLQ QETEIPEVGV RNLRPNTAYN FTLTTQHTGG DTDGWPSWLV
ARTSPQLLHT QPYVLNISEH GTVQVVLSRA TNFATVKRYS VVVVPVNKKD VRHPSTLNHE
VLVSNSISMK KRRRRRQTNG EMPYITAEFD AIDIEQIFVV GDAINYGGYI NQVLVRGLSY
KVFLRAMLKT PVSIFFIPSS RQSSLNPDPT DPTLLESSSD QLWILGPILA AIVILLIVFI
ILYTRRKKSK SGNQVKYMKP VSKHVTHEPH IQHDPVKMRR QNCKTPGMPS HPPISIHTFQ
HHVEQLRAND NLKFSQEYES IDPGQQFTWA QSTLEVNKPK NRYANVISYD HSRLTLSPID
GVPGSDYINA NYISGFRRQN AYIATQGPMR ETVSDFWRMV WEQRSSIICM MTKCEERCKV
KCEQYWPSGG SETYGLISVT LIDELELATY CVRTFNVVKS GLSDRREIKH FQFTAWPDHG
VPEHPTPVLN FMRRVKSHHQ PDAGPIVVHC SAGVGRAGCF ICIDAMLERI KYEETVDVYG
QVTCMRAERN YMVQTEDQYI FIHDALLEAI NSGNTELPAK DLFNHLHKLT TPDPDHPITG
MELEFKRLAS NKASASRFVS ANLPCNKFKN RLVNILPYEG TRVCLQPIRG VEGSDYINAS
FIDGYRQKRA YIATQGPLPE TTDDFWRTLW EHNSTIVVML TKLREQGRDK CHQYWPAERS
ARYQYFVVDP MSEYSMQQYM LREFKVTDAR DGQSRTVRQF QFTDWPEQAV PKSGEGFIDF
IGQVHKTKEQ FGQEGPITIH CSGVGRTGVF ITLSLALERM RFENLVDMFQ TVKMLRTQRP
AMVQTEDQYQ FCYRAALEYL GSFDHYAM
//
