ID H2Z3M4_CIOSA Unreviewed; 2890 AA.
AC H2Z3M4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000012186.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000012186.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR Ensembl; ENSCSAVT00000012328.1; ENSCSAVP00000012186.1; ENSCSAVG00000007178.1.
DR GeneTree; ENSGT00940000154280; -.
DR HOGENOM; CLU_000038_0_2_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 506..653
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 855..1003
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1680..1721
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2890 AA; 327628 MW; 767351DA3395D53A CRC64;
LKKCFEGIAK LRFLDNLDIQ AMFSSEGELV EFVDLISTSA ARGSVEKWLL QVEDMMLKSV
RDVIIRANQA YQEVERHVWV TEWPGQVVLY VSQMYWTSEV HEALQSNGLQ GLKDYVVVLQ
EQMSHIVDLV RGKLAKQTRT TLGALVTIDV HARDVITEMV KQEVSADNDF NWLAQLRYYW
QNDQARAHII NADVKYAYEY LGNSPRLVIT PLTDRCYRTL VGAFYLNLGG APEGPAGTGT
ETTKDLAKAL AVQCVVFNCS DGLDYLAMGK FFKGLASSGA WACFDEFNRI ELEVLSVIAQ
QMMCIQRAIQ THVDTFMFEG TELNLKPNCF VAITMNPGYA GRSELPDNLK VLFRTVAMMV
PDYALIAEIS LYSCGFLDAR NLSVKIVMTY RLCSEQLSSQ FHYDYGMRAV KAVLVAAGNL
KLKFPDENED ILLLRSIQDV NLPKFLSHDI PLFRGITSDL FPGVTLPEAD YELFLIAVHE
LCEKHNVQPV PVFLEKIIQT YEMMIVRHGF MLVGDPFAGK TKCLHVLAGA LSLMKDRVIY
KTINPKAVTM GQLFGEFDAI SHEWTDGNVA NTFREFSSTD TPDRKWVVFD GPIDTLWIES
MNTVLDDNKK LCLMSGEIIQ MSAPMSLIFE SQDLSQASPA TVSRCGMIYL EPLSLGWRPM
FKSWLHVLPP VLSEDNAKLI ESLFETFVEP TVRFVKKKCK EVMPYQESNL IRSMMYLFEL
LLHDAASADN ATDNKNIKIW IQSIFLFSVV WSVGAVVDLD GRHKFSDFIR TMQSGKDEEH
PLPASLGKFD VPIPDAGLVY DHYFQLNGRG KWALWTDLIK GNEVVPDKSV NVQNIMVPTM
DTARTAYLLD ICISHRRPIL FVGPTGTGKS VYIKDKLMNN LSKDKYLPAF VNFSAKTTAN
QTQGLIMSKL DKRRKGVYGP PMGKQCVIFV DDMNMPAREV YGAQPPIELL RQYFDHGNWY
DLSETSKISL VDIIIVAAMG PPGGARNPVT PRFTRHFNII STLEFSDETM VKIFTTLMST
HMKAHEWPSD LHSTAQQIVN ATMNVYKEAM VNLLPTPAKS HYTFNLRDFS RVVMGCLLMK
KQSIENKKTF IRLFVHEVFR VFYDRLVDAT DQSWLYNLTR TMVKDHFKEN YDNLFDHLAQ
PAMPDRLYEE VKSIDEFTNV VQLSLEEYNQ THKAQMDLVV FRYLLEHLSR ISRVLKSPGG
NALLVGVGGS GRQSLTRLAT AMAGMTLFQP EISKSYGIPE WKEDLKNLLR AAGAQGKKTV
FLITDTQIKD ESFLEDVDSL LNTAEVANLF AADEKQELIE AVRPVMAQNA GPNTDFSPLA
MFSFFVSRCR DNLHIIIAFS PIGDAFRNRL RQFPSLINCC TIDWFQPWPA DALELVANKF
LENLELSDHE RKEIVPICQH FHTSSRNLSE AFLSEMGRHN YVTPTSYLEL IASFKKLLNE
KRETVLKAKK RYMGGLDKLK FASAQVAEMQ KELQELQPQL IITAEENSKL LVVIEKETVI
VEERTKVVQA DEAVANEQAA ESKALKDECE SDLAEAIPAL EAAPADITIV KSMKNPPAGV
KLVMSAVCVM RDIKPEKIPD PSGKGDKILD YWGPSKKLLG DMNFLGALQT YDKDNIPVAI
MKKIRSEYMT NPDFDPVKVA KASSAAEGLC KWINAMEVYD RVAKVVAPKK IKLAAAEQSL
SETMAVLNAK RAELKEVQDR LAELQFNFKT ATEKKQQLEF QVDLCSKKLD RAQKLIGGLG
GEKTRWTQAA GDLQTQYDNL TGDVLISSGV IAYLGAFTAG FRKRCTSDWT KQCQVLYAHD
ITCSDNFSLS ATLGDLIKIR AWNIAGLPTD QFSVDNGVIV DNSRRWPLMI DPQGQANKWV
KNSEKENKLS VIKLTNTDYM RVMENSIQFG TPVLLENVAE ELDPSLEPLL LKQTFKQGEM
LCGVLCIRLG ENVIEYSSDF RFYITTKLRN PHYMPELATK VSLLNFMITP EGLEDQLLGI
VVAKERPELE EERNVLILQS ASNKKQLKEI EDKILYTLSS SEGNILEDES AILILDSSKV
LSDDIQKKQK IADITEQKIA ESREGYRPIA KHSSILFFSI TDLPNIDPMY QYSLMWFVNL
YINSIMDSNK SKILEKRLRY LTDHFTYNLY CNVCRSLFEK DKLLFSLILC ANLTLAKGEL
TREEYLFFLT GGVGLENKRA NPDSSWLSDK SWDEICRMKD LPAFRGFLDH FQDNVQEWRK
VYDLKEPQNA QLPAPWDRKL NEFQRMTAIR CLRPDKVVPM IRQFVLEKLG RKFVEPPPFD
LAKSYADSNK AIPLIFVLSP GADPMAALMK FAADKGFDGE KFNAISLGQG QGPIAARMIE
SAMKDGTWVA LQNCHLAVSW MPAMEKLCEE FNPETMHNDF RLWLTSYPSD KFPVTVLQNG
VKMTNEPPTG LRMNILQSYL SDPLSDPEFF SGCGEKSPVF EKLLFGLCFF HALVQERRKF
GPLGWNIPYG FNESDLRISV RQLQIFINEY EDIPFTAVTY LTGECNYGGR VTDDWDRRLL
RSVLKDFYSP PLVHEHKYKV SPSGNYYVPP SMAYEEYIEF IKAFPIAQQP EVFGMHENVD
ISKELQETRQ LFDSVLLALG SQVSAEGGAG KTDDALNEIS VDILDKLPKD FDLEAALERY
PVTYGESMNT VLVQEMERFN NLLRVIRSTL INLRKAIKGL VVMNSELEAV AGSLLIGKVP
AMWMKKSYPN LKPLGSYINN FLARLKFLQD WYDQGKPDIF WISGFFFTQA FLTGARQNYA
RKYTIPIDKL DFEYDVLPFD ETDDGAPPDG VYVHGLYLDG ARWDRKKGVL SEQHPKILFD
TVPIIWLKPN KTDNIKTGRD YNCPVYKTSE RKGTLSTTGH STNYVLAIRL PSDRPEDHWI
KRGTALLCAL
//
