ID H2ZIA5_CIOSA Unreviewed; 3057 AA.
AC H2ZIA5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Laminin subunit alpha-2 {ECO:0008006|Google:ProtNLM};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000017321.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000017321.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR Ensembl; ENSCSAVT00000017510.1; ENSCSAVP00000017321.1; ENSCSAVG00000010201.1.
DR GeneTree; ENSGT00940000161177; -.
DR HOGENOM; CLU_000301_0_0_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 14.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR PANTHER; PTHR10574:SF448; WING BLISTER, ISOFORM B; 1.
DR Pfam; PF00052; Laminin_B; 2.
DR Pfam; PF00053; Laminin_EGF; 16.
DR Pfam; PF00054; Laminin_G_1; 4.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF06009; Laminin_II; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00180; EGF_Lam; 16.
DR SMART; SM00281; LamB; 2.
DR SMART; SM00282; LamG; 5.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 10.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01248; EGF_LAM_1; 5.
DR PROSITE; PS50027; EGF_LAM_2; 9.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR PROSITE; PS51115; LAMININ_IVA; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 1..250
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 439..487
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 508..696
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 725..774
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 833..880
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 881..929
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 930..976
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1023..1068
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1069..1126
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1138..1333
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1412..1472
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1473..1519
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2063..2252
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2266..2446
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2451..2635
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2689..2861
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2866..3052
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 517..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2647..2674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2647..2663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 458..467
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 744..753
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 852..861
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 864..878
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 881..893
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 883..900
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 902..911
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 930..942
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 950..959
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1023..1035
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1025..1042
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1044..1053
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1069..1081
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1097..1106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1443..1452
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1473..1485
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1475..1492
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1494..1503
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 3057 AA; 337518 MW; B1AA12548F69B976 CRC64;
GLFPSVVNLA SHAEITSNAT CGERGPDKFC KLVQHVDRRT DRGQQCGICD QFSRNPSERH
AVENAIDGRG DRWWQSPTID QGYQYHRVTL TLDLKQVFQV AYVIIKAANS PRPGNWILEK
STDGVTWSPW QYFATSDREC LLKYGKVASQ LGAPNYKTDS EVMCTTYFSR LNPFQNGEIH
VSLINGRPSA ENPSFELVDF TSARYIRLRL QKIRTLHGDL MTLSIGSTQN DPSVTRRYYY
SIKDISIGGM CICYGHASTC PTNTQNGLFH CACEHNTVGF NCERCAPGFH QYKWMPGNNG
FQCEECNCHG HATECYYDPA VNERGDSLNT RGEYIGGGVC VGCRDGTAGI NCQSCVDGMY
RPLDVEADSS HPCLPCNCNA YGGTRISDSG PYNCVKDIDH IDAENDLFPG SCYCKVGYTG
QQCDKCAFGY TGFPYCEPCP CNTSGSLNID PCIGDCACKE HVTGDNCNQC KVGFYNLQRN
NPMGCDECFC NGATQSCVSS NLRWSTIHTN EGWEVRDQRG RRRTRPQIDP DLHEPYVEHG
PTARELGTTM YYWSAPARYL GNKLNSYGGT LRYTVSYDIL QGAQPMPIQA NDIILDGNGR
TVIYNHRGML ISPEIETEVA LKLASSVFGS RDGWVNAESL QPVSKADMIA VLSNLRRILI
RAVYSRNIGA VYRIHDVYMD SATPEGKGLP ASSVEICHCP PGYTGYSCQD CATGYWRNGE
QCFPCNCNHH SNICNKLNGA CENCQHSTIG IHCERCKPGY YGNALNGTSE DCQRCSCPLA
TTSNNFSPTC LTKQPGDMMC LECAVGNSGK RCETCSDGYF GNPFAPGGSC QPCSCNGNSG
ACNQLNGVCK FCKGHTAGDH CERCEAAYYG DAILRKNCGP CECNPIGSLS RQCDFVTGQC
PCRQDVYGRK CDACASNNYL SIEEKMCVPC DCNPIGSIMM QCRSDGSCVC RTGVVGKTCG
ICSTGYHSFG DGGCIECDCT HTNGHCNPAT GECVCPANTH GEGCMNCVDG SYQWSLNNGC
TLCNCSKAGS TSFTCDNITG QCPCKFEYTD KTCNRCRPGY YGYPNCKACN CLVDGTQAST
CLNDGTCECS DDGQCLCKAN VQGLHCDRCV AGAFGLSNEN EVGCTTCFCS RFLLQFAKAR
QSFETISLSL APVEVTNEIA SRSTVGVADD IALLDSNTAV RAMRSGPYYW RLPPQFNGDR
RLSYGGKLRY TIYFVSEFST PPGMRPEASV IIQGGNLQTI KYSMEDPHIK QTRAYVVPMQ
EFGWAHLDSN KNVTRDEFSL ILQNVNSILI KASYGFLMDQ SRLSEVYLDV AVAGVTGRGD
SATDLPPAYG IEECICPPGY SGLSCQNCMA GYMRVQREPN LGMCELCNCF NRSDSCDIFT
GKCLNCIDKF VGHNCETCET GYYFSGNSCH KCECPGAGAI NNFSPTCHSD GSDGIASYTC
DACQIGYEGK HCERCADGYF GDPTVPGGFC AKCGCNVAGS LDGACDKVTG QCNCDEGIKG
RICDRCSDKH VITTEGCREC NDECAGKLLL EIEEMVNRTN DVDIRDMFPP PWNRLIGARN
VTAQLQKILE NSSNSVMDAL ADMVKIPGNI TKTEMKVYPV VAQAKSCITV SSNASGKVNA
TREHVKQQIL QTAELNNTVE TVSNMATRLL HGLQNGTAQD AADIYSKVDI KMNEMRARNI
NQYKEMADTE LEFAKDMLEL VYTNFTARAN QTEPQAHLFN EELIKQVGEI ETKFRHLQME
LSNASTDIRV ATTKNRINNM ATMTNVTLDE AQKIVNAAID LYKSGLQNME VSVKSQHFIN
ELKAYASSTQ AEVEAVTLHN NNILGSDLQG LQMSSVKSAV EHSAQLQEDA RMMLEVYKNV
SAFSYNQTEA ASRWTNIIRL LVRANKTSKT AIKQGKAALS TATTDLGIRA NESLLRNMAI
LNEVAELRNT VNDLLRSLED HLRSSNHSAL NLTDQHNRLL SRIDKINAAP SLTSNELFTI
TRSSNKVLGE INKQLEGAQE NVRLLGETEL QVLQQGMRSV SEAKERTTSK LERVQLASES
VRANISNIRQ LIEDARRKAG SIRVSVSSKG KCAMAYKPTI TPGKTTEIVL TIQNSEPNNA
LLYLARPRQD YIVVELRDYK VTVTWDLGGG PGFVQNPLII KADTENLRSS PDWFKIIINR
RNQELNVTAY RESDKIATMT NVGGVSPGSY SMLDINNDDI LFVGGILNTT EVHEAVMYRT
FNGCMGEAFL QGRTVGLWNF REINNPEDCK GCIEIEVATD KEQTNLYSYY GRSYSVLRFN
NHDSKRTQIS IRLQSFSSEG LIVYTGSATH PDFYSIELNK GRIMLKLDLG NGVHNASTEN
QYNTGEWVQV TFRRFAGNSL LSIKTVNQSQ ENIWLRIQGS DESLNFTSGD VTCVGGFPSD
RTIKADVTKI SFVGCLKEFS QNNLLRSLKS TVVEDVARDS GVQTACPAEI TRDIGISNKG
FVELKPINLQ PTSSISITFN TRNEDAVLLF ATSDNRQLRR RRRQTDEAYY SMYVYDGFVH
TALKLPGSPH IRLTSKFNIY NDGRDHTATL HRRRENITLQ MNEDGDYVSE YLPRGADQTI
TVRRVFVGGI PAEFNSTKAV GTEKSLNGCV RDLMSNLLVN FKEAVQAKNS YFGTCAFVEF
EPQPTLTSAT PPNTFTSNSM NPPKPPRATT PNTQPPLSAG RMPVIGNFSA HFGLSRNSHV
TFKLKKNIAK KFTFDLKVRT LGRNGILVYA GHKTQVDFFA LKVKEGIPIF QFDNGRGRGE
ADGSIRINDG KWHRVDTLKK IKEKRIHIRG WCKNKKTTSP KGANIMGVDN ILYVGGLPES
FNSKKIGQLS SMDACIKDLV LNRKRKLNLS KPRSAHKVDQ CYKKMESGAF FNGKGYAIYS
EKYRVGPRML IEMEFRTWNP SGILLSINNR RSDGLGIELV NGSIYFRTDN GAGPFEAVYS
DASTQHNTGR KVKFNLCDGR WHSLIANKDM NSLSLVVDGN AVPTVVSRAT TNSADTKDPL
YVGGIPDGTT NQQQVRTNQN LQGCIRNVRL KTTQVVRFDE IHESVGVYPN SCPKRNK
//
