ID H2ZJC9_CIOSA Unreviewed; 2796 AA.
AC H2ZJC9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Fibrillin 2b {ECO:0008006|Google:ProtNLM};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000017695.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000017695.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSCSAVT00000017887.1; ENSCSAVP00000017695.1; ENSCSAVG00000010416.1.
DR GeneTree; ENSGT00950000183158; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 19.
DR Gene3D; 2.10.25.10; Laminin; 45.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF12662; cEGF; 4.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 31.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 7.
DR PIRSF; PIRSF036312; Fibrillin; 1.
DR SMART; SM00181; EGF; 45.
DR SMART; SM00179; EGF_CA; 44.
DR SUPFAM; SSF57196; EGF/Laminin; 10.
DR SUPFAM; SSF57184; Growth factor receptor domain; 12.
DR SUPFAM; SSF57581; TB module/8-cys domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 37.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 25.
DR PROSITE; PS50026; EGF_3; 33.
DR PROSITE; PS01187; EGF_CA; 17.
DR PROSITE; PS51364; TB; 9.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 97..129
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 135..178
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 193..234
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 235..275
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 280..338
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 393..437
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 438..478
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 479..520
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 553..592
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 598..654
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 702..739
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 740..775
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 784..825
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 847..887
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 892..946
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1005..1046
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1047..1084
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1167..1208
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1209..1246
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1251..1289
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1292..1332
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1333..1375
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1376..1416
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1417..1457
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1462..1518
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1535..1576
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1628..1683
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1691..1733
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1734..1771
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1776..1816
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1817..1855
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1856..1896
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1983..2038
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2052..2092
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2093..2133
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2177..2217
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2221..2261
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2266..2322
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2334..2371
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2417..2453
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2456..2494
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2540..2578
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 101..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 119..128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 557..567
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 706..716
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 744..754
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1821..1831
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2796 AA; 303056 MW; 8C56968C23657E71 CRC64;
LTGRNVCHEK GSTFCCPGWM TSVTGKSCTV AKCPEGSCGP RGLCTRPNEC MCSNGQTQER
CPREENERRC NMRCMNGGEC MDNQCRCPYG YTGPHCGQPI CGPGCLNGGR CIAPGRCACV
YGFTGMRCER DYRKGPCFHT RVNGTCKDEV PGVMCTKLFC CATVGEGWGH PCEECPARVG
NCTKGRLPPL CSDIDECEIM PGLCDGGTCR NTDGSFVCEC PKGYRADTQT HRCVDVNECA
SSDVCTYGNC INTDGGFICE CPPDYKLSSD STYCISDKPG RCYTAIESGM CARPLFELVR
RTMCCCTPTG EETLGKCFAA VGETAERCPA VGTRRFLCLS SSDNSLEQSI GIGWSQLSYE
THNEAHKCFT FILIYHTEYN RDCEDTSNSI RLDSGLCELL GDQACSNGRC VNQPEQRTYF
CECEVGYTSS DDGKQCLDID ECSQDGLCED GACVNTRGSY VCNCNDGFRP SATQLECEDI
NECVEQEGIC ENGRCVNAGG SFRCICNPGF FTSPDSTSCL DENECERDNM CANGECVNMD
GRYKCANGQS CSDINECRMN PCENGRCENS EGSFQCHCHR FQRLDSTGTR CVLDQTMGDC
FRGVRNGQCR ARNALTGTST RSDCCCALPG ATSAWGESCE PCPEVRDADY TVLCHEVEIS
NICELLVNPC ENGDCLRMGN NKYRCICNKG FVVADDQLSC VDVDECSKNL CSNGACRNTP
GSYSCTCHDG FLLRGDVCED IDECVSNPCT QARCVNEPGS YRCVCSDGFS LDVTGHICYD
VTVGRCWRSY VNNECSGNIG NRLLTKEECC NTLGQAWGNV NCRPCSDFTF PCDHGYKLNI
QTNECENINE CEIGVCEEGA ECVDLDGSFR CECSPGLTLR SDGTSCTDVR VGICYQDVSE
DGYCSGTSAD TILMTKHQCC CTVGQGWGSP CETCPEKNTQ AWRKLCIPDG LRFALGQSTR
FRFFFNAFFF PNLCIGGECK NTDTSFTCLC NQGYTLDESG NNCTDIDECV ISPGLCGNGV
CINTGGDFTC DCEEGYEDSV TLKVCTDIDE CSLPGHCTGG TCFNTEGSYE CACPPGRSLG
PDGTNCCALR PDLCEPNGRC ENMLGYYMCI CDVGYIPTPD ARDCVDIDEC LDNNGGCHMG
CTNTIGSYEC SCDDGFVLAF DGHTCADRDE CMEQMNRCDG GTCENTDGAF RCVCFDGFMA
TADLQFCEDI DECAMNANVC MHGKCHNTRG SYTCNCEQGY CVPQGQMICV DEDECEMSKH
NCHVNADCNN TEGGYNCHCI PGFHGDGFMC HDDDECAMGT ALCHEVATCT NKHGSYECNC
DEGYHGDGFL CSDKDDCIED DSLCGPHGQC LNVDGSFECD CPMGFVTTDD RKACKDIDEC
SIEGICVNGR CHNVPGTFRC VCLDGYEKDD QGANCTDVDE CTNLANCING MCVNTDGTYE
CQCPEGFQKN PTGIGCVDTR TGNCFNSAEG DELAPICTGQ IGTDVTRGTC CCIDNAGAWG
NPCELCPSVN SSEYHTLCPG GPGFRTNPIT VLLEDINECV EVPGVCRGGK CINGFGTYIC
ECSMGYQLNS ATKTCEDINE CEGDTSDNEY DVCGAGLCLN TVGSYNCQCP EGYKSIMGGR
KCEDIREKSC YRYYNASSSD CSSPLDFVLT RKKCCCFSNI GQGWNNPCEP CPATGSDAFA
SVCGSVDFIR TNDMCGQINN LCENGVCIST EDGGYTCECS RGYEFNRDLI SCEDIDECEE
EDLCFADSVC TNMPGSYVCS CMEGFLFDEI SGTCVDIDEC NLGSTCTNGA CTNTRGGFIC
DCNQGFVPIN NDKACEDVNE CDRDPCGRGV CQNVFGSFTC TCDTGFRISD NGDCVDKNEC
DEEGQCNNGI CDNTPGGFAC DCDEGYTVTP DGRVCIDTDE CTEDPIVCGI GTCQNMDGSF
KCYCPDGYTS ESGAACVDVN ECEAGDKCIN GACVNTPGGF ECDCPKNSIV SANKKTCIDQ
REAHCYEQES QGVCSLPGNH AVKISTCCCQ CTGGGWGSAE DDCEACPSNG TLEFKNICPN
GCGFTPDGIG EYLNECEKNN PCINGRCVNQ PGSFRCECTN GFTLDDTNRR CVDVNECVSS
EDACGNGTCT NTDGAFECDC DSGYYNGPEM TCLDVDECKP GLDLNQCVFR CVNTDGSFHC
DCPNGFELRE DGRMCKDTDE CASDDLNDCA ENGMTCKNMI GFFVCLCPSG YRSTTPGVCV
DQNECDLAGV CRNGNCVNLE GTFRCDCNEG YLYDEEHKMC LDTRTGFCYA QIHQRMCEVT
STTGLPFTRA ECCCNRGKGW AEAGEDCEEC PHPGTALFVK LCPHGVGFKP NGDDIDDCHV
TPGLCAHGTC INTLGAFRCA CSHGYESARS NKACIDINEC LATPNPCSFD CRNTEGSYEC
ICPKGYQIDA DNSACVDLDE CAAKRHNCQY LCINTVGAFK CECPHGFMQE GAQCVDKNEC
IDMPGICGPR GICRNDPGGY HCECPRGYRR DDMGQACMDV DECNGQQSSC AGSCHNVPGS
FRCMCSRGFR PTMYGRGCSD VDECVHSPCS RGQSCSNKVG SFQCGCPAGL VKTQRGCGDV
DECQMGGGSC NFGCRNSYGG FSCSCNNGFF RMGRGHCFGG FGMPPAPGMP PVVPRGYQPP
PNTVCYACMP GGDTRRRHKR SPEEGKFIEV SGRHGRGMVN TSYPIELYLN SAKLTRRTPL
LQLQPSLKQL RNNVRYRIVG GNDDRKFRIH TRGGSSILHF TEDALQQELA GLTQDLTIRG
FTTMDTQQVK QVAMDSELLE KAIEDILEFH VQVNVD
//
