ID H2ZKB1_CIOSA Unreviewed; 4449 AA.
AC H2ZKB1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000018027.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000018027.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR Ensembl; ENSCSAVT00000018224.1; ENSCSAVP00000018027.1; ENSCSAVG00000010617.1.
DR GeneTree; ENSGT00940000154076; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF4; DYNEIN AXONEMAL HEAVY CHAIN 17; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 1831..1967
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2109..2307
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2436..2581
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 747..774
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1535..1562
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3023..3067
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3253..3301
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4449 AA; 508016 MW; 5415CEA99C44BC31 CRC64;
FLQSKTLKTL NLKVDKWAKM IMQEESKILV QEFLDKTDYF CLLIYLTPAG QLNPSYEFPT
SIKQKGTYFV KKEKLGVTKE NVRTKLIVGD ISQIPLDHMS PLVDEFLSHL LSNDGNHQRW
PAVVSDDVLR HVHKLKSNVY VVAGHVKGKT LLPLPVGSEK VDNAKAEERR ALLHAIETVV
IDWSHQVRDV LKQESAQPLL EGKNPGPSVE IDFWNAKCTN LECIYNQLKT PKVKKMAAIL
ELSHSSYYPA LRDIFTDVVS ALREARDIQM YLKPLRSFLD DFEQVDFTEA IPKLAPLMHI
VCLIWSQSKC YNTPVRIIVL LREMCNFLIE VTCNFLSPED ILKGEVDESV EKVAAALKVL
HAFRASFDDY KGKIDTFYED KSKVKYWKFA PELVFSRMDN FINRLDIVME FFVRSQEFMK
LEKIEFGGVK GRVLSQLVLN IFDGFQDLYK VFGERTYNPL DPEDPAFEDD FDSFTQSLSD
LERQLANIIC QGFDDCSGMA SICKMLNIFG SLLDRPIIKA DFDHKYPILL RLFNTSLDKI
KQIFDEHVIA TANQPCVHKN QPPVAGQLKW VQELHERITW PMELLQHINH PIFHSEECDL
VFAKQEQMVK LIKEYENKIF EQWTSGVEEA CKFNLGQPLL KRNPDTQLIS VNFDPQLVAV
LREVRYMKYL NRLDIPDVAL ELYENHEMFR KYCANLDLTV AWYNEVRNSV VDVEYPLVEG
QLHEIDDVLR QAETQLCWKS EGIWEYIQAT RDRVNDLQVR VQKTKMNIEK IEKIMKTWSE
TPLFERKQSN PAAILNLEDR KDRLAKRYAM IIADGEAIHQ CVKENLNFFN AVESSEIWQA
YISYLDDMVI DGFFNCIFCS LNYFMENTDV SAIIPDVQPL FIAELELQSP DMVFRPSLME
GAPDGFLDLI EGLLVDIYKM STLVPRIAPQ VGQPDYKADM DDMAELAAMR GDLVSRVHEV
IDKAIAYSQG FLEYGALWTD DRQEFMKQFL TYGHILAPEE VEMHGDEGVP ETPPTLTQFK
EQIDSYEGLY QVISNVTATQ VFDSWFLVQI KPFKQALLNT VKRWSYMFKE HLINHVESSL
SDLKEFIKVA DLGLSKPIEE GDYDGLVECM GHLMAVRDRA DATDVMFEPL KQTIELLKAY
DQEMSEDVHL QLQELPEQWN NTRKLSVTVK QTVAPLQANE VSIIRRKCTS FDVKQHEFRE
KFRKELVFRF DCVAAYPNLD RMQENVLDLK TEMISLHESA GLFEVNVPDY KQLKACRREV
GLCKGVWDLV QLVRTSTDDW KTTLWADINV EQMDIDCKRF AKVHGLTDIR TLDKEARAWD
VFGGLDSLVK NMITSLRAVG DLQNPAIRDR HWHELMQAAK VRFTMDETTT LADLLKLNLH
NFEDEVREIV DKAVKEMGME KTLRELDVTW AAMDFEYEHH QRTQSPLIKS NEELVETLED
NQVQLQNLMT SKYIAHFLEE GSLGWQKLST ADSVLTIWLE VQRTWSHLES IFIGSEDIRA
QLPEDSKRFD GVDRDFKEIM ADAVTTPNVI EATNKKGLYE RLEDLQAKLT LCEKALAEYL
ETKRLAFPRF YFVSSSDLLD ILSNGNNPVE VSRHLAKLFD NMSKLKFEEE EGGEASKSAL
GMYSTEDEYV AFGELCHCTG QVELWLNRVM DAMRATVRNE LAEAVVTYEE KPRDQWLFDY
PAQVALTSTQ IWWSTEVGIS FARLEEGYEH ALKDYFKKQV QQLNTLIGLL IGSLTPNDRQ
KIMTICTIDV HARDVVAKLI QQKIESASEF VWQSQLRHRW DDEKKHCFAN ICDAQFVYSY
EYLGNTPRLV ITPLTDRCYI TLTQSLHLIM GGAPAGPAGT GKTETTKDLA RSLGIMVYVF
NCSEQMDYKS IGNIYKGLAQ TGAWGCFDEF NRISVEVLSV VAVQVKSIQD AIRFKKKRFI
FQGEEISLIP TVGIFITMNP GYAGRTELPE NLKALFRPCA MVVPDFELIC EIMLVAEGFL
EARILARKFI TLYTLCKELL SKQDHYDWGL RAIKSVLVVA GSLKRSDKTR PEEQVLMRAL
RDFNIPKIVT DDMPVFMGLI GDLFPALDVP RKRDLDLEKM CRQAVHDLKL QAEDNFVLKL
VQLDELLFVR HSVFVIGNAG TGKTQVLKSL MKCYQNMKRR PIWVDLNPKA VTNDELFGII
NPATREWKDG LFSTVMRDLS NVTHNGPKWI VLDGDIDPMW IESLNTVMDD NKVLTLASNE
RIPLTPSMRL LFEISNLRTA TPATVSRAGI LYLNPADLGW NPVVTSWIDK REIQSEKANL
TILFDKYIPA CLETLRGRFK TITPIPECAK IQMLCFLLEV LLTPENTPAD CPKELYELYF
VFACIWAFGG AMFQDQLIDY RVEFSKWWTT EFKTVKFPSA GTVFDYCIDS ETKKFLPWSE
SVPAFELDPE LPLQACMVPT AETRRIRYFM DLLMEIRRPV MLVGNAGAGK TVLVQDKLAA
LPDDFMVTNV PFNFYTTSMM LQGVLEKPLE KKAGRNFGPP GSKRLVYFID DMNMPEVDAY
GTVQPHTLIR QHMDYSHWYD RTKLILKDIN NVQYVACMNP TAGSFTINPR LQRHFSVFAV
SFPGQDALQV IYSSILTQHL QMGGFPVAVQ KMSNTLVQAA LALHAKINST FLPTAIKFHY
IFNLRDLSNI FQGILFSTSD CVKNISDLVR LWMHEASRVY CDKLIDQKDI EMFEKNKLEF
AKKYFDDIPD EVLTAEPLLF CHFSAGIGDP KYLAVSTWQA MNKLLVDGLE AYNEVNAVMN
LVLFEDAMSH IARINRILES PRGNALLVGV GGSGKQSLSR LAAFISGLEV FQITLRKGYG
IPDLKVDLGA LCIKAGLKNI GTMFLLTDAQ VPDEKFLVLV NDLLASGEIP ELLPEDEVEN
VISGVRNEVK GAGLEDTREN CWKFFIDRVR RQLKVVLCFS PVGSTLRVRG RKFPAVVNCT
QIDWFHEWPE EALQSVSLTF LQDIEGIDPE IKPSISQFMS YVHTSVNQTS KMYLANDRRY
NYTTPKSFLE QIKLYESLLG VKGKELQAKM ERLENGLTKL QSTAAQVDDL KAKLASQEVE
LQQKNEDADK LIHVVGIETE KVSKEKAIAD NEENKVAVFA VEVGEKQKSC ETDLAKAEPA
LAAAQEALNT LNKNNLTELK SFGSPPGAVV NVTAAVMVLL APNGKVPKDR SWKASKVMMA
KVDAFLEQLI NYDKENIHEN SLKAIRPYLD DPEFDYDFIK QKSGAAAGLC AWCINIVRFY
EVYCDVEPKR IALSKANSDL AAAQDKLSGI KAKIAQLDAN LAELTAKFEK ATSDKLKCQQ
EAESTTLTIN LANRLVGGLA SENVRWAEAV SGFKEQEKML CGDILLITAF VSYVGYFTRS
YRIEFMDQCW LPYMKKQEVP IPTTEGLDPL SMLTDDADIA EWNNEGLPSD RMSTENATIL
TNCQRWPLIV DPQLQGIQWI KRRYSNLKIV RLGQRGYLDV IEMGVSNGDT VFIENVEESV
DPVLEPLLGR NTIKKGRYIK IGDKEVEYHP SFRLILHTKL ANPHYQPEMQ AQCTLINFTV
TKDGLEEQLL AEVVRCERPD LEELKAKLTL QQNDFKITLK RLEDSLLSRL SAASGNFLGD
TALVENLETT KKTAAEIEIK VAEAKVTETK INEAREGYRV VALRASLLYF ILNDLNIINP
IYQFSLKAFN VVFSKAIERS EQSDDLKVRV SNLVQTTTYS VFQYTTRGLF ECDKLTFTAQ
VALQILLANK EINLVEMDFL LRFPVKMDST SPVDFLSNYS WGGIKVLSEF EDFRNLDRDI
EGSAKRWKKF AESECPEKEK FPQEWKNKSS LQKLCMMRAL RPDRMTYAVQ NFVEEKLGTQ
YVENRSVEFA KSYEESGPET PIFFVLSPGV NPLKDVEAIG VKLGFTMDKK NFHNVSLGQG
QEIVAEQALD LAAQEGHWVV LQNVHLVAKW LSTLEKKIEK YSIGSHKSYR VYVSAEPAAT
RDSHIIPQGI LESSIKITNE PPTGMQANLH KALDNFNQET LEMCSRETEF KSLLQSLCYF
HAVLSERKKF GPQGWNRPYP FNVGDLTISV NVLFNYLEAN SKVPWNDLRY LFCEIMYGGH
ITDDWDRKLC KTYLEVYMHP DQLEGELLLA PGYPVPPNMD YKGYHEYIDE VLPPESPYLY
GLHPNAEIGV LTTTSENLFR TLLEMQPKDA AGAGGGGATR EEKVKALLDE ILEKLPEEFN
IVELLSKVED RTPYIVVAFQ ECERMNILTK ELRQSLKQLD LGLKGELTIT SDMEELESAM
FFDSVPESWT KRAYPSMFGL TAWFADLLIR IKELESWTAD FQLPNVVWLG GLFNPQSFLT
AIMQSMARKN EWPLDKMCLQ CDATKKNKED FNSPPREGSY IHGLFMEGAR WDVQSGLMAE
SRLKELTPAM PVMFIKAIPV DRQETKNIYE CPVYKNKSRG PTYVWTFNLK TKEKSSKWIL
AGVALLLQV
//
