ID H2ZR03_CIOSA Unreviewed; 1091 AA.
AC H2ZR03;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000020019.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000020019.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; H2ZR03; -.
DR STRING; 51511.ENSCSAVP00000020019; -.
DR Ensembl; ENSCSAVT00000020233.1; ENSCSAVP00000020019.1; ENSCSAVG00000011751.1.
DR eggNOG; KOG1991; Eukaryota.
DR GeneTree; ENSGT00940000154666; -.
DR InParanoid; H2ZR03; -.
DR OMA; WVAKTSW; -.
DR TreeFam; TF300634; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR013713; XPO2_central.
DR PANTHER; PTHR10997:SF18; D-IMPORTIN 7_RANBP7; 1.
DR PANTHER; PTHR10997; IMPORTIN-7, 8, 11; 1.
DR Pfam; PF08506; Cse1; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 22..103
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REGION 920..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..952
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1091 AA; 124529 MW; 7886A9C7A201C2FB CRC64;
MDPNKVLNAL EATMNPNLRK EAEAQLDQMH KIAGFSPLLI QLIMSDEVQM AIRQSGAIYL
KNMCVQSWHE RSDKDGTPVT DVFSIHENDR SVIRTNIVKA IIHAPDIIRS QLTVIIHNII
KHDFPERWPN VVDDINIHLQ DESPRSWMGA LMALYQLVKT YEFKKPEART PVISAMKHLL
PVMLGMFRNL MEDNSASSAL LQKQLLKILY ALVQYSLPME LFNEKILDEW VHIMRVIIET
PPPPETSEVD ELERCELPWW KSKKWAVHFL ARVFERYGSP GSVSKEYNEF SEFFLKRYTV
SILQVLLKIF DAYRNKEYVS PRVLQQALHF LDQAVSHAHT WKVMKGAYHD LLKDIIFPLM
CFTDEDKETW EDDPHEYIRM KFDIFEDFLS PSSAAQHLLH SAASKRKQVL QKTMGFCYSV
LTDTTTSPES SRKKDGALHI IGSLADTLLK KKMYKDQLEL MLRTHVIPEL SSEVGFMRAR
ASWVIQHFSE AKFKKKENII NVVEALKHLL LNDGELPVRV EAAMAIQAFL SEQELAEKHC
VQYVRPIMQA LLQLVHETEN DDLTTIVQKV ICLYCEQVIP YAVEITQNLV SLVGSCTKEG
SATGDAGDND DKAVTAMGIL STIETVLDMM EEEREITLQL ESIVAPLVAH VLKTTNMGEE
GLLYYYEEIF SLMYSLTCQA ISPHMWEALP LIAEVFEDDA FDYFTDMMPV LHNFCTIDTP
TLLSNSKYLE IIFAMCKQIL EKETGEDPEC HAAKLLEVII LQCRGQIDQI AAGFDPTTLQ
SDVQPVVYSP TDQCIPLFVE ATLARLTREV KTSELRTMCL QVVIAALYYN PSLLIQTLES
MRFPNTSETI SEQFFRQWIN DVDCFLGIHD RRMCVLGLCT LMDLPHRPPC IEELSNRFIP
SLIVLFQGLV RAYKVQGEEA ASDSSDSSSE DEEEDFETAE LASDEDEIDE ESTEYLEMLQ
KKEDDEDDDA SDDEFGDEGE TMLEAFPTSM EAESSSVDEF VAFKQVHSCK INWGGLKWGW
GFKVGDPQWY NVLMTGLSDE QRKSLEEIYV LADQRHAAAE SKKIEKTGGY RFENASVPSS
FSFATTRPPT L
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