ID H2ZSG8_LATCH Unreviewed; 231 AA.
AC H2ZSG8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 {ECO:0000256|ARBA:ARBA00021915};
DE EC=2.5.1.108 {ECO:0000256|ARBA:ARBA00012221};
DE AltName: Full=Diphthamide biosynthesis protein 1 {ECO:0000256|ARBA:ARBA00032574};
DE AltName: Full=Diphtheria toxin resistance protein 1 {ECO:0000256|ARBA:ARBA00032789};
DE AltName: Full=S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1 {ECO:0000256|ARBA:ARBA00031690};
GN Name=DPH1 {ECO:0000313|Ensembl:ENSLACP00000000339.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000000339.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000000339.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-histidyl-[translation elongation factor 2] + S-adenosyl-L-
CC methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation
CC elongation factor 2] + H(+) + S-methyl-5'-thioadenosine;
CC Xref=Rhea:RHEA:36783, Rhea:RHEA-COMP:9748, Rhea:RHEA-COMP:9749,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:29979,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:73995; EC=2.5.1.108;
CC Evidence={ECO:0000256|ARBA:ARBA00001323};
CC -!- SIMILARITY: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
CC {ECO:0000256|ARBA:ARBA00010173}.
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DR EMBL; AFYH01222730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01222731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01222732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01222733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01222734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01222735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01222736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01222737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01222738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01222739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006010867.1; XM_006010805.2.
DR AlphaFoldDB; H2ZSG8; -.
DR STRING; 7897.ENSLACP00000000339; -.
DR Ensembl; ENSLACT00000000341.1; ENSLACP00000000339.1; ENSLACG00000000307.1.
DR GeneID; 102356549; -.
DR KEGG; lcm:102356549; -.
DR eggNOG; KOG2648; Eukaryota.
DR GeneTree; ENSGT00940000153694; -.
DR HOGENOM; CLU_037146_3_0_1; -.
DR InParanoid; H2ZSG8; -.
DR OMA; SYNTTEM; -.
DR OrthoDB; 5472575at2759; -.
DR TreeFam; TF105746; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000000307; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0090560; F:2-(3-amino-3-carboxypropyl)histidine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0017183; P:protein histidyl modification to diphthamide; IEA:InterPro.
DR Gene3D; 3.40.50.11840; Diphthamide synthesis DPH1/DPH2 domain 1; 1.
DR Gene3D; 3.40.50.11850; Diphthamide synthesis DPH1/DPH2 domain 2; 1.
DR InterPro; IPR016435; DPH1/DPH2.
DR InterPro; IPR042263; DPH1/DPH2_1.
DR InterPro; IPR042264; DPH1/DPH2_2.
DR InterPro; IPR035435; DPH1/DPH2_euk_archaea.
DR NCBIfam; TIGR00322; diphth2_R; 1.
DR PANTHER; PTHR10762:SF1; 2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1; 1.
DR PANTHER; PTHR10762; DIPHTHAMIDE BIOSYNTHESIS PROTEIN; 1.
DR Pfam; PF01866; Diphthamide_syn; 1.
DR PIRSF; PIRSF004967; DPH1; 1.
DR SFLD; SFLDS00032; Radical_SAM_3-amino-3-carboxyp; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 231 AA; 25368 MW; 125BD02DF7C295F7 CRC64;
MEPQSERPGP GEMELQPRAG GVRSAARGPQ RKVANQIPDE ILNNKDLQEA MKSLPNNYNF
EIPKTVWRIK AVQARRVALQ FPEGLLLFAC TISDIVERFT GAETLVMGDV TYGACCVDDF
TARALGADFM VHYGHSCLIP IDTTSGIKML YVFVDIKIDT AHFIETVRLN FPKAAALALV
STIQFVAALQ ASAQELCPEY DVTTPQCRPL SPGEILGCTS PRLERPVNAI M
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