ID H2ZWB0_LATCH Unreviewed; 878 AA.
AC H2ZWB0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Zinc finger FYVE-type containing 28 {ECO:0000313|Ensembl:ENSLACP00000001681.1};
GN Name=ZFYVE28 {ECO:0000313|Ensembl:ENSLACP00000001681.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000001681.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000001681.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the lst-2 family.
CC {ECO:0000256|ARBA:ARBA00008755}.
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DR EMBL; AFYH01178322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZWB0; -.
DR STRING; 7897.ENSLACP00000001681; -.
DR Ensembl; ENSLACT00000001694.1; ENSLACP00000001681.1; ENSLACG00000001504.1.
DR eggNOG; KOG1819; Eukaryota.
DR GeneTree; ENSGT00940000157217; -.
DR HOGENOM; CLU_007360_1_0_1; -.
DR InParanoid; H2ZWB0; -.
DR OMA; PELGYDR; -.
DR TreeFam; TF320752; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15731; FYVE_LST2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR043269; FYVE_LST2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46465; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR PANTHER; PTHR46465:SF2; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 808..864
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 310..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 878 AA; 97523 MW; 7CC69206E2E0D9E5 CRC64;
NMMRSSQDNV LNIINQIMDE CIPNNRANRD FCVKFPEEIR HDNLAGQLWF GAECLAAGSI
IMNREIESMA MRPLAKDLTR SLEEVRNIIR DQALRDLNVY TDKMKESLKQ FDSLFAEFEL
SYVSAMVPVK SPKEYYVQQE VIVLFCETVE RALKLGYLTQ DMIDDYEPAL MFTIPRLAIV
CGLVVYSEGP LNLDHKPEDM SELFRPFRTL LRKIRDLLQT LTEEELYTLE RNLCISQDVE
FPTRADPEVS SSIPPVVAAA SPVEDELLRK SENTEAELAC SMQYDEQELE QLNMMVHRVG
DEMSCLLSPP SVCQSPARRP GTRQSSSTEA SPSRQNLAIV TDEEDRVFFM DDLDGAGEAL
AGIEAAEDAF AVTQNGWSRS IVFLKQTEIN SNNNDSALGQ ITSSSVQSCS CLEGPDSQLY
LNGWDVNGED AETAEMIAHR TGGMKISATV IFNPKSPTVS DSPTVTLEAA DNDTSTTSDS
LPDGGENEAH KLSIAATNCL INSCVCCGSC EDGKEESSER LKEKISPTEV INASYSLVNS
KEIDPCSQER LKTECPGPLL AEIQNAKEEE CKSSNCPKCL AKVSGLQQVS SENGPQAEAD
NCSQQRKSEK RRQPTGEKDN RPSVQKMAHS WRRETGRNIM FTFSSQDRMC DSPLSSISSS
DCESVSVTTC SLSSTYTQSS CSSEDIDQEE IQLALQAAKL TTREKIRSRF HSSNDLIHRL
FVCISGGVAD QLQTNYASDL RSILKTLFEV MATKPETEGK EKQTKVGQGL RSAALEDCTL
CQETISSSEI AAKARDGDFE DPPDWVPDEV CSYCTACKAP FTVIRRKHHC RSCGKIFCSR
CSSHSAPLPR YGQMKPVRVC THCYMFHVTP FYSDKAGI
//
