ID H2ZXT9_LATCH Unreviewed; 365 AA.
AC H2ZXT9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Bone morphogenetic protein 3 {ECO:0000256|ARBA:ARBA00013361};
GN Name=BMP3 {ECO:0000313|Ensembl:ENSLACP00000002210.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002210.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002210.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AFYH01104997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01104998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZXT9; -.
DR STRING; 7897.ENSLACP00000002210; -.
DR Ensembl; ENSLACT00000002228.1; ENSLACP00000002210.1; ENSLACG00000001975.1.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000159775; -.
DR HOGENOM; CLU_020515_10_0_1; -.
DR InParanoid; H2ZXT9; -.
DR OMA; HWGTINN; -.
DR TreeFam; TF316134; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19393; TGF_beta_BMP3; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF144; BONE MORPHOGENETIC PROTEIN 3; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 253..365
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 365 AA; 41906 MW; F54205DB48B22F66 CRC64;
AGTIGSKNLH LFNLTSLTKS EDILSATLHY FIGDRMNSTH SYLLSRCCDR HGPRKHFHIE
LSVWSFASVG NQTRTLGHFL INVSSVYRDF LSWQWKDITS MLSQAKQNNE LLVGIEIVSD
GPYSWKKLLS HHSPYILVYA NDSAVLELDS VVSSLQSHKR SLVHKLHKLE NPAKDTISQR
RMKRSTNVLL PLQNNELPGA EYQYNGPKTW EEQNPYKTLQ ARMAKRQDKK KRKNNRQKAQ
TLQFDEKTLK KARRKQWNEP RNCARRYLKV DFADIGWSEW IISPKSFDAY YCSGSCQFPM
PKSLKPSNHA TIQSIVRAVG VVPGIPEPCC VPEKMSSLSI LFFDEDKNVV LKVYPNMTVQ
SCACR
//
