ID H2ZYE2_LATCH Unreviewed; 1097 AA.
AC H2ZYE2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A10 {ECO:0000313|Ensembl:ENSLACP00000002413.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002413.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002413.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR EMBL; AFYH01150341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01150342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01150343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01150344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01150345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01150346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01150347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01150348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01150349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01150350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZYE2; -.
DR STRING; 7897.ENSLACP00000002413; -.
DR Ensembl; ENSLACT00000002433.1; ENSLACP00000002413.1; ENSLACG00000002155.1.
DR eggNOG; KOG1172; Eukaryota.
DR GeneTree; ENSGT00940000156972; -.
DR HOGENOM; CLU_002289_5_2_1; -.
DR InParanoid; H2ZYE2; -.
DR OMA; EDAEKEX; -.
DR TreeFam; TF313630; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF32; SODIUM-DRIVEN CHLORIDE BICARBONATE EXCHANGER; 1.
DR Pfam; PF07565; Band_3_cyto; 2.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 489..511
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 523..546
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 566..588
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 595..617
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 704..722
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 742..760
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 790..809
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 830..854
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 890..912
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 962..979
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 985..1002
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 56..164
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 270..413
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 460..968
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 266..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1097 AA; 123592 MW; 4FECB6688FD3B770 CRC64;
TLDTPSQRVQ FILGTEDDDE EHIPHDLFTE LDEICMREGE DGEWRETARW LKFEEDVEDG
GERWSKPYVA TLSLHSLFEL RSCILNGTVL LDMRANTIEE IADMILDQQV GSGQLNEDVR
QRVHGALLKQ HHHQNQKKLS NRIPIVRSFA DIGRKQSEPH SMDKNAFYLL TMVMGLQWSP
LSDTFAMKIS ERYINPILPS PPLEFPVAII IKKKNYFVLS QKNSASFDES ATKLTQYGLY
LKKCVICAVF KKRICVRNKV RLPQSGHMVS PQSAPANIDG KSEGGREDST VDFTKVDLHF
MKKIPPGAEA SNILVGELQF LDHPLVAFVR LSPAVVLSGI AEVPIPTRFL FILLGPLGKG
QQYHEIGRSI ATLMTDEVFH DVAYKAKDRN DLVAGIDEFL DQVTVLPPGE WDPSIRIEPP
KNVPSQEKRK TAGVPNGMAT HDELKEHGGH SGPELQRTGK LFGGLILDIK RKARFFWSDF
RDAISLQCLA SFLFLYCACM SPVITFGGLL GEATEGSISA IESLFGASMT GIAFSLFAGQ
PLTILGSTGP VLVFEKILFK FCKEYGLSYL SLRACIGLWT AFLCILLVAT DASSLVCYIT
RFTEEAFAAL ICIIFIYEAL EKLFHLSETY PINMQNNLEQ LTHYSCICIA PNNPSNKTLQ
YWEQHNITAS EVSWENLTVS DCAALHGEFL GTACGHHGPY VPDVLFWSII LFFSTFILSS
FLKQFKTSRY FPTKVRSIVS DFAVFLTILT MVLIDFALGI PSPKLQVPSN FKPTRDDRGW
LVNPLGLNPW WTVLAAVIPA LLCTILIFMD QQITAVIVNR KEHKLKKGCG YHLDLLIVAV
MLGICSIMGL PWFVAATVLS ITHVNSLKLE SECSAPGEQP KFLGILEQRV TGLMIFVLMG
SSVFLTTVLK FIPMPVLYGV FLYMGVSSLK GIQFFDRIKL FGMPPKHQPD FIYLRHVPLR
KVHLFTVLQL TCLILLWVIK ASRAAIVFPM MVLALVFIRK LMDFFFTKRE LSWLDDLMPE
SKKKKLDDVE KEVRKEEQSM LMEEEGTVHL PLEGHYSIYF CRDDPSVINI SDEMAKTSVW
KTLVKNNENS KNKESSF
//
